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Neurochemical Characterization of Hexachlorophene Induced Brain Oedema

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Recent Developments in Toxicology: Trends, Methods and Problems

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 14))

Abstract

Hexachlorophene induces severe generalized oedema of the cytotoxic type in white matter of CNS producing paralytic symptoms which disappear spontaneously within some weeks after termination of drug treatment. The aim of the present study was to provide an additional neurochemical characterization of hexachlorophene oedema at the paralytic climax of its occurrance. The parameters used were

  1. (i)

    the kinetic constants calculated on the Ca2+ -dependence of K+ -stimulated dopamine release from striatum slices, which represents a very sensitive probe for synaptic membrane function, and

  2. (ii)

    the activity of high affinity Ca2+-ATPase in a crude brain synaptosomal fraction, possibly connected with release mechanisms.

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References

  • Blaschke M, Fischer H-D, Schmidt J (1988) Zur peroxidativen Schädigung der synaptosomalen hochaffinen Ca2+-ATPase und ihrer pharmakologischen Beeinflußbarkeit. Biomed Biochim Acta 47:887–893

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Author information

Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, Medical University “Carl Gustav Carus” Dresden, Lingnerplatz 1, O-8010, Dresden, Germany

    K. Andreas, M. Blaschke, E. Bergsträsser, H.-D. Fischer & J. Schmidt

Authors
  1. K. Andreas
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  2. M. Blaschke
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  3. E. Bergsträsser
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  4. H.-D. Fischer
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  5. J. Schmidt
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Institut für Pharmakologie und Toxikologie, Universität Leipzig, Universitätsbereich Medizin, Härtelstraße 16-18, O-7010, Leipzig, Germany

    Wolf Diether Wiezorek

  3. Veterinärmedizinische Fakultät, Institut für Pharmakologie, Pharmazie und Toxikologie, Universität Leipzig, Zwickauer Straße 55, O-7010, Leipzig, Germany

    Siegfried Golbs

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© 1991 Springer-Verlag Berlin Heidelberg

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Andreas, K., Blaschke, M., Bergsträsser, E., Fischer, HD., Schmidt, J. (1991). Neurochemical Characterization of Hexachlorophene Induced Brain Oedema. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-74936-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51422-0

  • Online ISBN: 978-3-642-74936-0

  • eBook Packages: Springer Book Archive

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