Abstract
The prophylactic experimental approach to counter cyanide poisoning involves pretreatment with methemoglobin producers viz. sodium nitrite (NaNO2) and aminophenols (Kiese and Weger 1965). 4-Dimethylaminophenol (DMAP), a rapid methemoglobin former was suggested to give greater protection than nitrite (Kiese and Weger 1969). However, its clinical application is limited because of its toxicity (Szinicz et al 1979) and inability to offer a sustained protection for longer duration, when personnel are at risk to cyanide exposure while negotiating an industrial disaster. A protracted methemoglobinemia is presumed to offer sustained protection against cyanide poisoning. Hence, in the present study, the efficacy of sustained methemoglobinemia was studied in rats as a result of co-administration of NaNO2 (slow methemoglobin producer) and DMAP in appropriate doses. A reduction in DMAP dosages is also envisaged based on methemoglobin kinetics.
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© 1991 Springer-Verlag Berlin Heidelberg
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Bhattacharya, R., Jeevaratnam, K., Raza, S.K., Gupta, S.D. (1991). Cyanide Antagonism in a Rodent Model. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_48
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DOI: https://doi.org/10.1007/978-3-642-74936-0_48
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