Abstract
The dithiols DL-2,3-dimercaptopropanol (British Anti-Lewisite, BAL; Peters et al 1945), DL-2,3-dimercaptopropanesulfonate (DMPS; Petrunkin 1956) and meso-2,3-dimercaptosuccinic acid (DMSA; Liang et al 1957) are effective arsenic antidotes. The possibility of oral application to reduce the As2O3 toxicity is proved for DMPS and DMSA, but not for BAL. Why BAL should not be given orally has not been discussed (Aposhian 1983; lit. in press). On the other hand, in one paper so far (Kreppel et al 1989) oral treatment with BAL has been shown to be effective in reducing lethality in acute As2O3 poisoning. Hence, the effectiveness of BAL in hydrophilic and in lipophilic solvent, DMPS, and DMSA in reducing the arsenic content of tissues after oral administration was investigated.
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References
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© 1991 Springer-Verlag Berlin Heidelberg
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Schäfer, B., Kreppel, H., Reichl, F.X., Fichtl, B., Forth, W. (1991). Effect of Oral Treatment with Bal, DMPS or DMSA Arsenic in Organs of Mice Injected with Arsenic Trioxide. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_47
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DOI: https://doi.org/10.1007/978-3-642-74936-0_47
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