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Comparative Nephrotoxicity Studies of Cisplatin and its Iodinized Derivative in Rats

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Recent Developments in Toxicology: Trends, Methods and Problems

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 14))

Abstract

Cisplatin, cis-diammine-dichloroplatin (CP) is a widely used anticancer drug. But its curative effect is connected with nephrotoxicity. Reaction products of CP and low molecular weight proteins are involved in the toxic effect. Passage through membranes and binding to proteins are determined among other things by physicochemical properties of the substance. Therefore it was decided to investigate the nephrotoxicity of a CP derivative which is very similar in structure, but differs in lipophilicity. This iodinized derivative, cis-diamminediiodoplatin (CP-J2), was determined to have a higher n-octanol/water partitition coefficient than CP (0.25 and 0 respectively).

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References

  • Appenroth D, Gambaryan S, Bakhteeva V, Winnefeld K, Schröter H, Bräunlich H (1990a) Triidothyronine (T3) increases cisplatin nephrotoxicity in young and adult rats. J Appl Toxicology 10:395–399

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  • Appenroth D, Gambaryan S, Gerhjardt S, Kersten L, Bräunlich H (1990b) Age dependent differences in the functional and morphological impairment of the kidney following cisplatin administration. Exp Pathol 38:231–239

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Author information

Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, FSU, Löbderstraße 1, O-6900, Jena, Germany

    D. Appenroth, S. Kessler, K. Winnefeld & H. Bräunlich

Authors
  1. D. Appenroth
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  2. S. Kessler
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  3. K. Winnefeld
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  4. H. Bräunlich
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Institut für Pharmakologie und Toxikologie, Universität Leipzig, Universitätsbereich Medizin, Härtelstraße 16-18, O-7010, Leipzig, Germany

    Wolf Diether Wiezorek

  3. Veterinärmedizinische Fakultät, Institut für Pharmakologie, Pharmazie und Toxikologie, Universität Leipzig, Zwickauer Straße 55, O-7010, Leipzig, Germany

    Siegfried Golbs

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© 1991 Springer-Verlag Berlin Heidelberg

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Appenroth, D., Kessler, S., Winnefeld, K., Bräunlich, H. (1991). Comparative Nephrotoxicity Studies of Cisplatin and its Iodinized Derivative in Rats. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_43

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  • DOI: https://doi.org/10.1007/978-3-642-74936-0_43

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51422-0

  • Online ISBN: 978-3-642-74936-0

  • eBook Packages: Springer Book Archive

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