Influence of Bile Acids on the Development of Hepatic Transport of Organic Anions

Abstract

Transfer of xenobiotics and endogeneous compounds from blood into bile is immature at birth. Bile acids play a dominant role in bile formation and are able to influence the biliary excretion of various drugs (Gregus and Fischer 1979). Maturation of bile acid excretion was found to be on the 20th day of life, whereas the biliary excretion of exogeneous organic anions matures between the 20th and 30th days of life in rats (Barth et al 1977, 1986). Despite choleretic effect taurocholic acid did not enhance the low biliary transport capacity for indocyanine green in 20 day old rats (Barth et al 1981). It was the aim of the present experiments to elucidate the effects of other bile acids on the development of the biliary excretion process. In 20 and 60 day old rats the biliary excretion of eosin was determined after simultaneous administration of eosin and bile acids.