Skip to main content

The Effect of Monoclonal Antibodies on Dipyrone-Induced Rat Liver Cytochrome P450

  • Conference paper
Recent Developments in Toxicology: Trends, Methods and Problems

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 14))

Abstract

Dipyrone is used to estimate cytochrome P450(P450)-dependent biotransformation in humans especially via phenobarbital(PB)-inducible isozymes. However, there exist discrepancies concerning specificity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Aitio A (1978) A simple and sensitive assay of 7-ethoxycoumarin deethylation. Anal Biochem 85:488–491

    Article  PubMed  CAS  Google Scholar 

  • Burke MD, Prough RA, Mayer RT (1977) Characteristics of a microsomal cytochrome P-448-mediated reaction ethoxyresorufin O-deethylation. Drug Metab Disp 5:1–8

    CAS  Google Scholar 

  • Burke MD, Thompson S, Elcombe CR, Halpert J, Haaparanta T, Mayer RT (1985) Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between induced cytochromes P-450. Biochem Pharmacol 34:3337–3345

    Article  PubMed  CAS  Google Scholar 

  • Lubet RA, Mayer RT, Cameron JW, Nims RW, Burke MD, Wolff T, Guengerich FP (1985) Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat. Arch Biochem Biophys 238:43–48

    Article  PubMed  CAS  Google Scholar 

  • Nebert DW, Gelboin HV (1968) Substrate inducible microsomal aryl hydrocarbon hydroxylase in mammalian cell culture. I. Assay and properties of the induced enzyme. J Biol Chem 243:6242–6249

    PubMed  CAS  Google Scholar 

  • Omura T, Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239:2370–2378

    PubMed  CAS  Google Scholar 

  • Park SS, Fujino T, Miller H, Guengerich FP, Gelboin HV (1984) Monoclonal antibodies to phenobarbital-induced rat liver cytochrome P-450. Biochem Pharmacol 33:2071–2081

    Article  PubMed  CAS  Google Scholar 

  • Park SS, Fujino T, West D, Guengerich FP, Gelboin HV (1982) Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450. Cancer Res 42: 1798–1808

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kraul, H., Pasanen, M., Pelkonen, O. (1991). The Effect of Monoclonal Antibodies on Dipyrone-Induced Rat Liver Cytochrome P450. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_40

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74936-0_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51422-0

  • Online ISBN: 978-3-642-74936-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics