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Influence of Iron Chelators, 1,2-Dialkyl-3-Hydroxypyridin-4-Ones, on the Lipid Peroxidation and Glutathione Level in the Liver of Mice

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Recent Developments in Toxicology: Trends, Methods and Problems

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 14))

Abstract

Pretreatment with deferoxamine (DFO) protects male mice against the haloalkane induced hepatoxicity. This effect is closely related to the ability of DFO to bind iron and to suppress iron-dependent lipid peroxidation which may be induced by various chemicals (Siegers et al 1988). In this paper the influence of some iron chelators of the group of 1,2-dialkyl-3-hydroxypyridin-4-ones on the lipid peroxidation (LP) and glutathione depletion was investigated. LP was induced by indium chloride, cadmium chloride or carbon tetrachloride.

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References

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Author information

Authors and Affiliations

  1. Dept. of Pharmacology, Medical Faculty Charles University, 30166, Pilsen, ČSFR

    V. Eybl, D. Caisová & J. Koutenský

  2. Dept. of Haematology, RHSM, London, UK

    G. J. Kontoghiorghes

Authors
  1. V. Eybl
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  2. D. Caisová
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  3. J. Koutenský
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  4. G. J. Kontoghiorghes
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Institut für Pharmakologie und Toxikologie, Universität Leipzig, Universitätsbereich Medizin, Härtelstraße 16-18, O-7010, Leipzig, Germany

    Wolf Diether Wiezorek

  3. Veterinärmedizinische Fakultät, Institut für Pharmakologie, Pharmazie und Toxikologie, Universität Leipzig, Zwickauer Straße 55, O-7010, Leipzig, Germany

    Siegfried Golbs

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© 1991 Springer-Verlag Berlin Heidelberg

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Eybl, V., Caisová, D., Koutenský, J., Kontoghiorghes, G.J. (1991). Influence of Iron Chelators, 1,2-Dialkyl-3-Hydroxypyridin-4-Ones, on the Lipid Peroxidation and Glutathione Level in the Liver of Mice. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_37

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  • DOI: https://doi.org/10.1007/978-3-642-74936-0_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51422-0

  • Online ISBN: 978-3-642-74936-0

  • eBook Packages: Springer Book Archive

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