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Inhibition of Platelet Aggregation and Thromboxane A2 Production by Chlorophenoxy Acid Herbicides

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Recent Developments in Toxicology: Trends, Methods and Problems

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 14))

Abstract

In toxic doses chlorophenoxy acid herbicides cause hemorrhages in different organs of animals. The compounds are structurally related to some antiplatelet drugs, such as P-chlorophenoxyisobutyric acid (clofibric acid) and 4-[2-(benzene-sulfonamide)-ethyl]phenoxyacetic acid (sulotroban = BM 13.177). It has been found recently that chlorophenoxy acid herbicides inhibit human platelet aggregation (Elo et al. 1987). The mechanism of the antiplatelet action of these herbicides is not known, while sulotroban is an effective antagonist of thromboxane (Tx) A2 (Patscheke et al. 1986). The present paper reports that some chlorophenoxy acid herbicides are potent inhibitors of human platelet aggregation and thromboxane production.

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References

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Kuopio, P.O. Box 1627, SF-70211, Kuopio, Finland

    P. Ylitalo, M. Ylihakola, H. A. Elo & H.-M. Koponen

  2. Department of Biomedical Sciences, University of Tampere, P.O. Box 607, SF-33101, Tampere, Finland

    E. Seppälä & H. Vapaatalo

Authors
  1. P. Ylitalo
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  2. M. Ylihakola
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  3. H. A. Elo
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  4. H.-M. Koponen
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  5. E. Seppälä
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  6. H. Vapaatalo
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Institut für Pharmakologie und Toxikologie, Universität Leipzig, Universitätsbereich Medizin, Härtelstraße 16-18, O-7010, Leipzig, Germany

    Wolf Diether Wiezorek

  3. Veterinärmedizinische Fakultät, Institut für Pharmakologie, Pharmazie und Toxikologie, Universität Leipzig, Zwickauer Straße 55, O-7010, Leipzig, Germany

    Siegfried Golbs

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© 1991 Springer-Verlag Berlin Heidelberg

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Ylitalo, P., Ylihakola, M., Elo, H.A., Koponen, HM., Seppälä, E., Vapaatalo, H. (1991). Inhibition of Platelet Aggregation and Thromboxane A2 Production by Chlorophenoxy Acid Herbicides. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_35

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  • DOI: https://doi.org/10.1007/978-3-642-74936-0_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51422-0

  • Online ISBN: 978-3-642-74936-0

  • eBook Packages: Springer Book Archive

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