Metabolic and Toxicological Studies on the Anticoagulant Rodenticide, Flocoumafen

  • G. E. Veenstra
  • D. E. Owen
  • K. R. Huckle
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 14)

Abstract

Flocoumafen (STORM*), 4-hydroxy-3-[1,2,3,4-tetrahydro-3-[4-(4-trifluormethylbenzyloxy) phenyl]-1-naphthyl] coumarin (Fig. 1) is a 4-hydroxycoumarin-derived anticoagulant rodenticide.

Keywords

Toxicity Corn Petroleum Phenyl Warfarin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Huckle KR, Hutson DH, Warburton PA (1988) Elimination and accumulation of the rodenticide flocoumafen in rats following repeated oral administration. Xenobiotica 18:1465–1479PubMedCrossRefGoogle Scholar
  2. Huckle KR, Hutson DH, Logan CJ, Morrison BJ, Warburtn PA (1989a) The fate of the rodenticide flocoumafen in the rat: retention and elimination of a single oral dose. Pestic Sc 25:297–312CrossRefGoogle Scholar
  3. Huckle KR, Morrison BJ, Warburton PA (1989b) The percutaneous fate of the rodenticide flocoumafen in the rat: role of non-biliary intestinal excretion. Xenobiotica 19:63–74PubMedCrossRefGoogle Scholar
  4. Huckle KR, Warburton PA, Forbes S, Logan CJ (1989c) Studies on the fate of flocoumafen in the Japanese quail (Coturnix coturnix japonica). Xenobiotica 19:51–62PubMedCrossRefGoogle Scholar
  5. Suttie JW (1978) The fat soluble vitamins. In Handbook of Lipid Research, Vol. 2, ed. H. F. Deluca, Plenum Press, New YorkGoogle Scholar
  6. Suttie JW (1980) Mechanism of action of Vitamin K: Synthesis of gamma-carboxyglutamic acid. Critical Reviews in Biochemistry 8:191–223PubMedCrossRefGoogle Scholar
  7. Thijssen HHW, Baars LGM (1987) Hepatic uptake and storage of Warfarin. The relation with the target enzyme vitamin K 2,3-epoxide reductase. J Pharmacol Exp Ther 243:1082–1088PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • G. E. Veenstra
    • 1
  • D. E. Owen
    • 1
  • K. R. Huckle
    • 1
  1. 1.Health, Safety and Environment DivisionShell Internationale Petroleum MaatschappijThe HagueThe Netherlands

Personalised recommendations