Preclinical Assessment of the Cardiotoxic Potential of Anthracycline Antibiotics: N-L-Leucyl-Doxorubicin
The primary task of industrial toxicologists is to provide a comprehensive assessment of the adverse effects of selected chemical substances in several animal species and over a broad range of doses. Increasingly, their collaboration is also required when a compound has caused serious toxicity in humans or animals, and when it is decided to modify the chemical structure, in an effort to reduce or to eliminate the undesirable properties. In such programs it is often necessary to assess a considerable number of newly synthesized substances. Moreover, the results of the toxicity tests must be available within a short period of time, and they must be quantitative, so as to provide a rational basis for the synthesis of new derivatives. It is evident that the standard toxicological procedures cannot be used for these purposes, and that a toxicological screening approach has to be developed which differs fundamentally from that on which the conventional safety assessment programs are based (Zbinden et al 1984a). The main differences between conventional safety testing programs and toxicological screening are summarized in Table 1.
KeywordsCholesterol Toxicity Leukemia Neuropathy Doxorubicin
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