Abstract
Reports on toxic effects of platinum coordination complexes on the endocrine pancreas are missing with exception of cis-DDP itself (Goldstein et al 1983). Recently, oxoplatin (trans-dihydroxy-cis-dichlorodiammine-platinum [IV]) an oxygenated derivative of cis-DDP has been described by Presnov and Konovalova (1988), Fig. 1. As indicated by the maximally tolerated dose levels, oxoplatin has been found to be about 3 times less toxic than cis-DDP when administered daily to rats for 5 consecutive days (Härtl et al 1989).
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References
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© 1991 Springer-Verlag Berlin Heidelberg
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Hillesheim, H.G., Kohnert, K.D., Fält, F., Besch, W., Schröer, H.P., Hoffmann, H. (1991). Toxic Action of Platinum Coordination Complexes on the Endocrine Pancreas of the Rat. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_16
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DOI: https://doi.org/10.1007/978-3-642-74936-0_16
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