Mortality and Neoplastic Lesions in Untreated Sprague-Dawley Rats

  • J. Kaspareit-Rittinghausen
  • F. Deerberg
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 14)

Abstract

Data on tumour types and frequencies of rodent species obtained from longevity studies can be helpful tools for the interpretation of carcinogenicity studies, since conclusions concerning carcinogenicity of a particular substance require the knowledge of incidences of naturally occuring neoplasms of the animals under study. In the present paper a report is given on the mortality and the most important neoplastic lesions of untreated Han: SPRD rats kept in a life-span study from weaning to their natural death.

Keywords

Formalin Cage Adenocarcinoma Adenoma Oncol 

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References

  1. Anver MR, Cohen BJ, Lattuada CP, Foster JS (1982) Age-associated lesions in barrier-reared male Sprague-Dawley rats: A comparison between Hap: (SD) and Crl:COBS(R)CD(R)(SD) stocks. Exp Aging Res 8:3–24PubMedCrossRefGoogle Scholar
  2. Cohen GL, Anver MR, Ringler DH, Adelmann RC (1978) Age-associated pathological changes in male rats. Fed Proc 37:2848–2850PubMedGoogle Scholar
  3. Coleman GL, Barthold SW, Osbaldison OW, Foster SJ, Jonas AM (1977) Pathological changes during aging in barrier-reared Fischer 344 rats. J Geront 32:256–278Google Scholar
  4. Goodman DG, Ward JM, Squire RA, Chu KC, Linhart MS (1971) Neoplastic and nonneoplastic lesions in aging F 344 rats. Toxicol and Appl Pharmacol 48:237–248CrossRefGoogle Scholar
  5. Goodman DG, Squire RA, Paxton MB, Reichhardt WD, Chu KG, Linhardt MS (1980) Neoplastic and nonneoplastic lesions in aging Osborne-Mendel rats. Toxicol and Appl Pharmacol 55:433–447CrossRefGoogle Scholar
  6. Löhrke H, Hesse B, Goerttler K (1982) Spontaneous tumours in male and female specified pathogen-free Sprague-Dawley rats (outbred stock Sut:SDT). Z Versuchstierkd 24:225–230PubMedGoogle Scholar
  7. Morii S, Fujii T (1973) Spontaneous tumours in Sprague-Dawley rats. Exp Animals 22:127–138Google Scholar
  8. Muraoka Y, Itoh M, Yamashita F, Hayashi Y (1977) Spontaneous tumours in aged SD-JCL rats. Exp Pathol 26:13–22CrossRefGoogle Scholar
  9. Prejean JD, Peckham JC, Casey AE, Gridwold DP, Weisburger EK, Weisburger JH (1973) Spontaneous tumours in Sprague-Dawley rats and Swiss mice. Cancer Res 33:2768–2773PubMedGoogle Scholar
  10. Reznik G, Reznik-Schüller H (1980) Pathology of the clitoral and preputial glands in aging F 344 rats. Lab Anim Sci 30:845–851PubMedGoogle Scholar
  11. Solleveld HA, Haseman JK, McConnel EE (1984) Natural history of body weight gain, survival and neoplasia in F 344 rats. J Natl Cancer Inst 72:929–940PubMedGoogle Scholar
  12. Suzuki H, Mohr U, Kimmerle G (1979) Spontaneous endocrine tumours in Sprague-Dawley rats. J Cancer Res Clin Oncol 95:184–196CrossRefGoogle Scholar
  13. Thompson SW, Huseby RA, Fosc MA, Davis CL, Hunt RD (1961) Spontaneous tumours in the Sprague-Dawley rat. J Natl Cancer Inst 27:1037–1057PubMedGoogle Scholar
  14. Thompson SW, Hunt RD (1963) Spontaneous tumours of the Sprague-Dawley rat: Incidence rates of some types of neoplasms as determined by serial sections versus single section techniques. Ann NY Acad Sci 108:832–845CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • J. Kaspareit-Rittinghausen
    • 1
  • F. Deerberg
    • 2
  1. 1.Squibb-von Heyden, Abt. ToxikologieRegensburg 13Germany
  2. 2.Central Institute for Laboratory Animal BreedingHannoverGermany

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