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Effect of Nifedipine on Atherosclerosis in Cholesterol-Fed Rabbits and Watanabe Heritable Hyperlipidemic Rabbits

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Adalat® in the Asian Pacific Region

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Abstract

Anticalcifying drugs such as EDTA (Wartman et al. 1967), EHDP (Rosenblum et al. 1975), and thiophene compounds (Chan et al. 1978) have been reported to suppress atherosclerosis in cholesterol-fed rabbits without lowering serum cholesterol levels. Kramsch et al. (1980, 1981) reported that lanthanum, an inorganic calcium antagonist, suppressed atherosclerosis in cholesterol- fed rabbits and monkeys, and Henry and Bentley (1981) demonstrated that nifedipine, a calcium channel blocker, suppressed atherosclerosis in cholesterol-fed rabbits. Thereafter, the calcium channel blockers diltiazem (Ginsburg et al. 1983), verapamil (Rouleau et al. 1983), and nicardipine (Willis et al. 1985) were also reported to suppress atherosclerosis in cholesterolfed rabbits. However, other insvestigators have reported that nifedipine (Stender et al. 1984), nicardipine, and diltiazem (Naito et al. 1984) did not suppress atherosclerosis in cholesterol-fed rabbits. In Watanabe heritable hyperlipidemic rabbit (WHHL rabbit; Watanabe 1980), which lacks low-density lipoprotein (LDL) receptors and is a unique model of human familial hypercholesterolemia, Van Niekerk et al. (1984) demonstrated that atherosclerosis wasnot suppressed by nifedipine.

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References

  • Blumlein SL, Sievers R, Kidd P, Parmley WW (1984) Mechanism of protection from atherosclerosis by verapamil in the cholesterol-fed rabbit. Am J Cardiol 54: 884–889

    Article  PubMed  CAS  Google Scholar 

  • Chan CT, Wells H, Kramsch DM (1978) Suppression of calcific fibrous-fatty plaque formation in rabbits by agents not affecting elevated serum cholesterol levels. The effect of thiophene compounds. Circ Res 43: 115–125

    Google Scholar 

  • Etingin OR, Hajjar DP (1985) Nifedipine increases cholesteryl ester hydrolytic activity in lipid-laden rabbit arterial smooth muscle cells. A possible mechanism for its antiatherogenic effect. J Clin Invest 75: 1554–1558

    Google Scholar 

  • Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497–509

    PubMed  CAS  Google Scholar 

  • Ginsburg R, Davis K, Bristow MR et al. (1983) Calcium antagonists suppress atherogenesis in aorta but not the intramural coronary arteries of cholesterol-fed rabbits. Lab Invest 49: 154–158

    PubMed  CAS  Google Scholar 

  • Hata Y, Shigematsu H, Tsushima M, Aihara K (1978) A xerographic method for the quantitative assessment of atherosclerotic lesions. Atherosclerosis 29: 251–258

    Article  PubMed  CAS  Google Scholar 

  • Havel RJ, Eder HA, Bragdon JH (1955) The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34: 1345–1353

    Article  PubMed  CAS  Google Scholar 

  • Henry PD, Bentley KI (1981) Suppression of atherogenesis in cholesterol-fed rabbit treated with nifedipine. J Clin Invest 68: 1366–1369

    Article  PubMed  CAS  Google Scholar 

  • Kramsch DM, Aspen AJ, Apstein CS (1980) Suppression of experimental atherosclerosis by the Ca -antagonist lanthanum. J Clin Invest 65: 967–981

    Article  PubMed  CAS  Google Scholar 

  • Kramsch DM, Aspen AJ, Rozler LJ (1981) Atherosclerosis: prevention by agents not affecting abnormal levels of blood lipids. Science 213: 1511–1512

    Article  PubMed  CAS  Google Scholar 

  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265–275

    PubMed  CAS  Google Scholar 

  • Naito M, Kuzuya F, Asai K, Shibata K, Yoshimine N (1984) Ineffectiveness of Caanagonists nicardipine and diltiazem on experimental atherosclerosis in cholesterol-fed rabbits.Atherosclerosis 51: 343 - 344

    CAS  Google Scholar 

  • Nakao J, Ito H, Ooyama T, Chang WC, Murota S (1983) Calcium dependency of aortic smooth muscle cell migration induced by 12-L-hydroxy-5, 8, 10, 14-eicosatetraenoic acid. Effect of A23187, nicardipine and trifluoperazine. Atherosclerosis 46: 309 - 319

    CAS  Google Scholar 

  • Rosenblum IY, Flora L, Eisenstein R (1975) The effect of disodium ethane-1-hydroxy-1, 1-diphosphonate ( EHDP) on a rabbit model of athero-arteriosclerosis. Atherosclerosis 22: 411-424

    Google Scholar 

  • Rouleau JL, Parmley WW, Stevens J et al (1983) Verapamil suppresses atherosclerosis in cholesterol-fed rabbits. J Am Coll Cardiol 1: 1453 - 1460

    Article  PubMed  CAS  Google Scholar 

  • Sadanaga T, Hikida K, Tameto K, Matsushima Y, Ohkura Y (1982) Determination of nifedipine in plasma by high-performance liquid chromatography. Chem Pharm Bull (Tokyo) 30: 3807 - 3809

    CAS  Google Scholar 

  • Sparrow MP, Johnstone BM (1964) A rapid micro-method for extraction of Ca and Mg from tissue. Biochim Biophys Acta 90: 425 - 426

    PubMed  CAS  Google Scholar 

  • Stein O, Leitersdorf E, Stein Y (1985) Verapamil enhances receptor-mediated endocytosis of low density lipoproteins by aortic cells in culture. Arteriosclerosis 5: 35 - 44

    Article  PubMed  CAS  Google Scholar 

  • Stender S, Stender I, Nordestgaard B, Kjeldsen K (1984) No effect of nifedipine on atherogenesis in cholesterol-fed rabbits. Arteriosclerosis 4: 389 - 394

    Article  PubMed  CAS  Google Scholar 

  • Terashita K, Orimo H, Nakamura T, Ooshima J, Harasawa M (1984) Calcium metabolism and arteriosclerosis, I: the effect of Ca-antagonist on the release of PGI2 from cultured rat aortic smooth muscle cells. J Jpn Atheroscler Soc 12:851-856 (English abstr) Van Niekerk JLM, Hendriks T, De Boer HHM, Van’t Laar A (1984) Does nifedipine suppress atherogenesis in WHHL rabbits? Atherosclerosis 52: 91 - 98

    Google Scholar 

  • Wartmann A, Lampe TL, McCann DS, Boyle AJ (1967) Plaque reversal with Mg EDTA inexperimental atherosclerosis: elastin and collagen metabolism. J Atheroscler Res 7: 331 - 341

    Article  Google Scholar 

  • Watanabe Y (1980) Serial inbreeding of rabbits with hereditary hyperlipidema (WHHLrabbit). Incidence and development of atherosclerosis and xanthoma. Atherosclerosis 36: 261 - 268

    Article  PubMed  CAS  Google Scholar 

  • Willis AL, Nagel B, Churchill V et al. (1985) Antiatherosclerotic effects of nicardipine and nifedipine in cholesterol-fed rabbits. Arteriosclerosis 5: 250 - 255

    Article  PubMed  CAS  Google Scholar 

  • Wolinsky H, Daly MM (1970) A method for the isolation of intima-media samples from arteries. Proc Soc Exp Biol Med 135: 364 - 368

    PubMed  CAS  Google Scholar 

  • Yoshida Y, Mitsumata M, Ooneda G, Takatama M (1983) Growth of smooth muscle cells in aortic atherosclerotic plaques of rabbits. J Jpn Atheroscler Soc 11: 1165-1172 (English)

    Google Scholar 

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Authors and Affiliations

  1. First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan

    Y. Ishikawa, N. Watanabe, N. Miyazaki, T. Taniguchi & H. Fukuzaki

  2. Institute for Experimental Animal, Kobe University School of Medicine, Kobe, Japan

    Y. Watanabe

Authors
  1. Y. Ishikawa
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  2. N. Watanabe
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  3. N. Miyazaki
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  4. T. Taniguchi
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  5. Y. Watanabe
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  6. H. Fukuzaki
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Editor information

Editors and Affiliations

  1. Hallstrom Institute of Cardiology, Royal Prince Alfred Hospital, University of Sydney, 2050, Camperdown, NSW, Australia

    David T. Kelly

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© 1989 Springer-Verlag Berlin Heidelberg

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Ishikawa, Y., Watanabe, N., Miyazaki, N., Taniguchi, T., Watanabe, Y., Fukuzaki, H. (1989). Effect of Nifedipine on Atherosclerosis in Cholesterol-Fed Rabbits and Watanabe Heritable Hyperlipidemic Rabbits. In: Kelly, D.T. (eds) Adalat® in the Asian Pacific Region. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74911-7_5

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  • DOI: https://doi.org/10.1007/978-3-642-74911-7_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51388-9

  • Online ISBN: 978-3-642-74911-7

  • eBook Packages: Springer Book Archive

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