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Effect of Nifedipine on Relaxation and Early Left Ventricular Filling During Postpacing Ischemic Period

  • Conference paper
Adalat® in the Asian Pacific Region

  • 33 Accesses

Abstract

Nifedipine has been shown to improve left ventricular performance during ischemia (Emanuelsson and Holmberg 1983; Lorell et al. 1981; Nelson et al. 1984; Tiefenbrunn et al. 1983). Although it has been reported that nifedipine can improve diastolic properties of hypertrophic cardiomyopathy (Lorell et al. 1982), whether it can modify relaxation and ventricular filling abnormalities during ischemia is not yet know. Since left ventricular relaxation and filling are important functions for ventricular ejection, which comes next in the cardiac cycle, we studied the effects of nifedipine on relaxation and early ventricular filling in patients with coronary artery disease during postpacing ischemic periods.

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References

  • Aroesty JM, McKay RG, Heller GV, Royal HD, Als AV, Grossman W (1985) Simultaneous assessment of left ventricular systole and diastolic dysfunction during pacing-induced ischemia. Circulation 71: 889

    Article  PubMed  CAS  Google Scholar 

  • Bahler RC, Martin P (1985) Effects of loading conditions and inotropic state on rapid filling phase of ventricle. Am J Physiol 248: H523

    PubMed  CAS  Google Scholar 

  • Bonow RD, Bacharach SL, Green MV, Kent KM, Rosing DR, Lipson LC, Leon MB, Epstein ST (1981) Impaired left ventricular diastolic filling in patients with coronary artery disease: assessment with radionuclide angiography. Circulation 64: 315

    Article  PubMed  CAS  Google Scholar 

  • Carroll JD, Hess OM, Hirzel HO, Krayenbuehl HP (1983) Exercise-induced ischemia: the influence of altered relaxation on early diastolic pressures. Circulation 67: 521

    Article  PubMed  CAS  Google Scholar 

  • Carroll JD, Hess OM, Hirzel HO, Krayenbuehl HP (1983b) Dynamics of left ventricular filling at rest and during excercise. Circulation 68: 59

    Article  PubMed  CAS  Google Scholar 

  • Emanuelsson H, Holmberg S (1983) Mechanisms of anginal relief after nifedipine: a hemodynamic and myocardial metabolic study. Circulation 68: 124

    Article  PubMed  CAS  Google Scholar 

  • Fujita M, Sasayama S, Kawai C, Eiho S, Kuwahara M (1981) Automatic processing of ineventriculograms for analysis of regional myocardial function. Circulation 63: 1065

    Article  PubMed  CAS  Google Scholar 

  • Grossman W, Mann JT (1978) Evidence for impaired left ventricular relaxation during acute ischemia in man. Eur J Cardiol 7 [Suppl]: 239

    PubMed  Google Scholar 

  • Hammermeister KE, Warbasse JR (1974) The rate of change of left ventricular volume in man. II. Diastolic events in health and disease. Circulation 49: 739

    Google Scholar 

  • Henry PD, Shuchleib R, Borda U, Roberts R, Williamson JR, Sobel BE (1978) Effects of nifedipine on myocardial perfusion and ischemic injury in dogs. Circ Res 43: 372

    PubMed  CAS  Google Scholar 

  • Henry PD, Shuchleib R, Davis J, Weiss ES, Sobel BE (1977) Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart. Am J Physiol 233: H677

    PubMed  CAS  Google Scholar 

  • Hirota Y (1980) A clinical study of left ventricular relaxation. Circulation 69: 190

    Google Scholar 

  • Ishida Y, Meisner JS, Tsujioka K, Gallo JI, Yoran C, Frater RW, Yellin EL (1986) Left ventricular filling dynamics: influence of left ventricular relaxation and left atrial pressure. Circulation 74: 187

    Article  PubMed  CAS  Google Scholar 

  • Kennedy JW, Trenholme SE, Kasser IS (1970) Left ventricular volume and mass from single plane angiogram. A comparison of anteroposterior and right anterior oblique methods. Am Heart J 80: 343

    Google Scholar 

  • Kumade T, Karliner JS, Pouler H, Gallagher KP, Shirato K, Ross J jr (1979) Effects of coronary occlusion on early ventricular diastolic events in conscious dogs. Am J Physiol 237: H542

    Google Scholar 

  • Lorell BH, Turi Z, Grossman W (1981) Modification of left ventricular response to pacing tachycardia by nifedipine in patients with coronary artery disease. Am J Med 71: 667

    Article  PubMed  CAS  Google Scholar 

  • Lorell BH, Paulus WJ, Grossman W, Wynne J, Cohn PF (1982) Modification of abnormal left ventricular diastolic properties by nifedipine in patients with hypertrophic cardiomyopathy. Circulation 65: 499

    Article  PubMed  CAS  Google Scholar 

  • Malacoff RF, Lorell BH, Mudge GH jr, Holman BL, Idoine J, Bifolck L, Cohn PF (1982) Beneficial effects of nifedipine on regional myocardial blood flow in patients with coronary artery disease. Circulation 65 [Suppl I]: 132

    Google Scholar 

  • McLaurin LP, Rolett EL, Grossman W (1973) Impaired left ventricular relaxation during pacing-induced ischemia. Am J Cardiol 32: 751

    Article  PubMed  CAS  Google Scholar 

  • Murakami T, Hess OM, Krayenbuehl HP (1985) Left ventricular function before and after diltiazem in patients with coronary artery disease. J Am Coll Cardiol 5: 723

    Article  PubMed  CAS  Google Scholar 

  • Nakamura Y, Konishi T, Nonogi H, Sakurai T, Sasayama S, Kawai C (1986) Myocardial relaxation in atrial fibrillation. J Am Coll Cardiol 7: 68

    Article  PubMed  CAS  Google Scholar 

  • Nakamura Y, Wiegner AW, Bing OHL (1986b) Measurement of relaxation in isolated rat ventricular myocardium during hypoxia and reoxygenation. Cadiovasc Res 20: 690

    Article  CAS  Google Scholar 

  • Nelson GIC, Slike B, Ahuja RC, Verma SP, Hussain M, Taylor SH (1984) Hemodynamic effects of nifedipine during upright exercise in stable angina pectoris and either normal or severely impaired left ventricular function. Am J Cardiol 53: 451

    Article  PubMed  CAS  Google Scholar 

  • Noble MIN, Milne EN, Goerke RJ, Carlsson E, Domenesch RJ, Sauners KB, Hoffman JIE (1969) Left ventricular filling and diastolic pressure-volume relations in the conscious dog. Circ Res 24: 269

    PubMed  CAS  Google Scholar 

  • Paulus WJ, Serizawa T, Grossman W (1982) Altered left ventricular diastolic properties during pacing-induced ischemia in dogs with coronary stenosis. Potentiations by caffeine. Circ Res 50: 218

    Google Scholar 

  • Sasayama S, Nonogi H, Miyazaki S, Sakurai T, Kawai C, Eiho S, Kuwahara M (1985) Changes in diastolic properties of the regional myocardium during pacing-induced ischemia in human subjects. J Am Coll Cardiol 5: 599

    Article  PubMed  CAS  Google Scholar 

  • Savitzky A, Golay MJE (1964) Smoothing and differentiation of data by simplified least squares procedures. Anal Chem 36: 1627

    Article  CAS  Google Scholar 

  • Serizawa T, Carabello BA, Grossmann W (1980) Effect of pacing-induced ischemia on left ventricular diastolic pressure-volume relations in dogs with coronary stenosis. Circ Res 46: 430

    PubMed  CAS  Google Scholar 

  • Tamiya K, Sugawara M, Sakurai Y (1979) Maximum lengthening velocity during isotonic relaxation at preload in canine papillary muscle. Am J Physiol 237: H83

    PubMed  CAS  Google Scholar 

  • Tiefenbrunn AJ, Sobel BE, Ludbrook PA (1983) Salutary effect of nifedipine in pacinginduced angina: relation to afterload reduction. Cathet Cardiovasc Diagn 9: 583

    Article  PubMed  CAS  Google Scholar 

  • Weisfeldt ML, Armstrong P, Scully HE, Sanders CA, Daggett WM (1974) Incomplete relaxation between beats after myocardial hypoxia and ischemia. J Clin Invest 53: 1626

    Article  PubMed  CAS  Google Scholar 

  • Weiss JL, Frederiksen JW, Weisfeldt ML (1976) Hemodynamic determinants of the time course in canine left ventricular pressure. J Clin Invest 58: 751

    Article  PubMed  CAS  Google Scholar 

  • Yamagishi T, Ozaki M, Kumada T, Ikezono T, Shimizu T, Furutani Y, Yamaoka H, Ogawa H, Matsuzaki M, Matsuda Y, Arima A, Kusukawa R (1984) Asynchronous left ventricular diastolic filling in patients with isolated disease of the left anterior descending coronaryartery: assessment with radionuclide ventriculography. Circulation 69: 933

    Article  PubMed  CAS  Google Scholar 

  • Zacca NM, Verani MS, Chahine RA, Miller RR (1982) Effect of nifedipine on exerciseinduced left ventricular dysfunction and myocardial hypoperfusion in stable angina. Am J Cardiol 50: 689

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Third Dept. of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan

    Y. Nakamura, H. Nonogi, S. Miyazaki, Y. Kihara, T. Konishi & C. Kawai

  2. Second Dept. of Medicine, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Toyama, Japan

    S. Sasayama

Authors
  1. Y. Nakamura
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  2. S. Sasayama
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  3. H. Nonogi
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  4. S. Miyazaki
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  5. Y. Kihara
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  6. T. Konishi
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  7. C. Kawai
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Editor information

Editors and Affiliations

  1. Hallstrom Institute of Cardiology, Royal Prince Alfred Hospital, University of Sydney, 2050, Camperdown, NSW, Australia

    David T. Kelly

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© 1989 Springer-Verlag Berlin Heidelberg

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Nakamura, Y. et al. (1989). Effect of Nifedipine on Relaxation and Early Left Ventricular Filling During Postpacing Ischemic Period. In: Kelly, D.T. (eds) Adalat® in the Asian Pacific Region. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74911-7_4

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  • DOI: https://doi.org/10.1007/978-3-642-74911-7_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51388-9

  • Online ISBN: 978-3-642-74911-7

  • eBook Packages: Springer Book Archive

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