Nifedipine-Induced Reperfusion in Stable Angina and Postinfarction Cases

  • R. F. Abarquez
  • V. M. Sison
  • R. G. Sy
  • N. S. Abelardo
  • R. R. Castillo
  • R. D. Jara
  • O. E. Enoveso
Conference paper


Most of the diagnostic and therapeutic approaches to angina pectoris focus on epicardial coronary artery abnormalities. Yet, pathophysiologic and clinical manifestations are not always related to the degree or extent of the coronary pathology. Although significant occlusive disease with total coronary flow reduction results in transmural pathology, patients may have no angina, ischemia,electrophysiologic changes, or lactate production at rest [1–4], some may have angina due to subendocardial ischemia [5–6], and 28%-50% may have no myocardial infarction [7–9]. After coronary bypass surgery of noninfarction cases only 21%–75% have improved wall motion [10–12]. Thus, survival is predicted by the degree of residual left ventricular dysfunction rather than by the number or extent of diseased vessels [13]. Likewise, factors other than fixed obstuctive lesions of the epicardial vessels may contribute to ventricular function.


Coronary Flow Reserve None None Coronary Arteriography Coronary Spasm Thallium Imaging 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. F. Abarquez
    • 1
  • V. M. Sison
    • 1
  • R. G. Sy
    • 1
  • N. S. Abelardo
    • 1
  • R. R. Castillo
    • 1
  • R. D. Jara
    • 1
  • O. E. Enoveso
    • 1
  1. 1.Philippine Heart CenterMedical Arts BuildingQuezon CityPhilippines

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