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Hemodynamic and Neurohumoral Effects of Nifedipine Slow-Release Tablet in the Treatment of Hypertension

  • T. Santoso
  • D. Ismail
  • A. M. Rahman
  • M. N. T. Wangge
  • H. Mansjoer
  • T. Sugiarti
  • N. Abdurahman
Conference paper

Abstract

Nifedipine has been found effective in the acute [1–7] and long-term treatment [8–12] of hypertension. Hemodynamically the drug acts as a powerful arterial vasodilator [8, 13, 14] leading to a reduction in the elevated peripheral vascular resistance which is the hallmark of the established phase of essential hypertension [14, 15]. Following oral administration similar bioavailability was found for the various oral forms: 10-mg quick-release capsules or tablets and the 20-mg slow-release tablets. Plasma half-life for the standard capsule or tablet formulation is only 2.5-5 h. On the other hand, a very long half-life of 12–15 h may be observed after the administration of the retard tablets [16], making them theoretically more suitable for the long-term treatment of hypertension than the other oral nifedipine preparations.

Keywords

Left Ventricular Mass Plasma Renin Activity Systemic Vascular Resistance Plasma Noradrenalin Fractional Shorten 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • T. Santoso
    • 1
  • D. Ismail
    • 1
  • A. M. Rahman
    • 1
  • M. N. T. Wangge
    • 1
  • H. Mansjoer
    • 1
  • T. Sugiarti
    • 1
  • N. Abdurahman
    • 1
  1. 1.Department of Internal MedicineUniversity of Indonesia, Medical SchoolJakartaIndonesia

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