Interleukin 3: A Multilineage Hematopoietic Growth Factor

  • C. Stocking
  • W. Ostertag

Abstract

Unlike the other known interleukins, interleukin 3 (IL-3) does not regulate or direct the function of the cells of the mature lymphoid compartment but rather supports the survival, stimulates the proliferation, and directs the differentiation of pluripotent stem cells and committed precursors in the myeloid (including erythroid) compartment. The major advances in the study of the growth and differentiation of the hematopoietic system have relied on three major classes of in vitro systems:
  1. a)

    short-lived (less than 3 weeks) cultures in which soluble factors are required for growth and differentiation (Pluznik and Sachs 1965; Bradley and Metcalf 1966);

     
  2. b)

    long-term cultures (3 months or more) dependent on complex underlayers of marrow stromal cells, which support the continuous proliferation of pluripotential hematopoietic stem cells and certain of their progeny (Dexter et al. 1977); and

     
  3. c)

    factor-dependent hematopoietic stem and progenitor cell lines (Greenberger et al. 1979; Dexter et al. 1980).

     

Keywords

Leukemia Interferon Histamine Disulfide Cyclosporin 

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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • C. Stocking
  • W. Ostertag

There are no affiliations available

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