Distinctive Features of Nerve Growth Factor: Structure, and Function
During development of the nervous system, a variety of genetic and epigenetic factors are known to determine the survival and maintenance of selective neuronal populations. Nerve growth factor (NGF) still serves as the only example of a neurotrophic factor whose physiological role is firmly established. Although the the actions of NGF were originally thought to be restricted to the sympathetic and neural crest derived sensory neurons, it is clear that effects of NGF extend to the central nervous system and beyond. For example, cholinergic neurons in the basal forebrain not only bind and internalize NGF but respond with the induction of choline acetyltransferase (for reviews see Korsching 1986; Thoenen et al. 1987). Furthermore, the detection of NGF and NGF receptors in nonneuronal regions such as testis (Ayer-LeLievre et al. 1988) muscle (Raivich et al. 1985) and the minune system (Ernfors et al. 1988) and of NGF proliferative effects on mast cells (Aloe and Levi-Montalcini 1977; Matsuda et al. 1988) suggests that NGF possesses a far broader range of actions than previously believed.
KeywordsPC12 Cell Nerve Growth Factor Nerve Growth Factor Receptor Nerve Growth Factor Treatment Nerve Growth Factor mRNA
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- Escandon E, Chao MV (1989) Developmental expression of the chicken nerve growth factor receptor gene during brain morphorgenesis. Dev Brain Res (in press)Google Scholar
- Kujuba DA, Lim RW, Varnum BC, Herschman HR (1987) Induction of transiently expressed genes in PC-12 pheochromocytoma cells. Oncogene 1:257–262Google Scholar
- Raivich G, Zimmermann A, Sutter A (1985) the spatial and temporal pattern of β-NGF receptor expression in the developing chicken embryo. EMJO J. 4:637–644Google Scholar
- Shelton DL, Reichardt LF (1986) Studies on the expression of the β nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distingt populations of neurons. Proc Natl Acad Sci USA 83:2714–2718PubMedCrossRefGoogle Scholar
- Sukhatme VP, Cao X, Chang LC, Tsai-Morris CH, Stamenkovich S, Ferreira PCP, Cohen DR, Edwards SA, Shows TB, Curran T, LeBeau MM, Adamson ED (1988) A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 53:37–43PubMedCrossRefGoogle Scholar