Structure and Function of Signal-Transducing, Heterotrimeric Guanosine Triphosphate Binding Proteins

  • P. Gierschik
  • D. Sidiropoulos
  • K. Dieterich
  • K. H. Jakobs


The ability to sense and appropriately respond to changes in the concentration of extracellular signaling molecules is one of the most important properties of an individual cell within a multicellular organism. Many signaling molecules are relatively hydrophilic and thus not able to penetrate the plasma membrane. Responsive cells must therefore be equipped with efficient mechanisms capable of
  1. a)

    perceiving the presence of these mediators at their outer surface,

  2. b)

    transmitting this information across their plasma membrane, and

  3. c)

    translating it into a form that can be read by a complex enzyme machinery inside the cell.



Adenylate Cyclase Cholera Toxin Pertussis Toxin Subunit Dissociation Effector Moiety 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • P. Gierschik
  • D. Sidiropoulos
  • K. Dieterich
  • K. H. Jakobs

There are no affiliations available

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