Interactions of 1α,25-Dihydroxyvitamin D3 and Hematopoietic Cells
The biologically active metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], is recognized as a major hormonal regulator of calcium metabolism in man (Norman et al. 1982), Recently, evidence has been obtained for a wider biological role of 1α,25(OH)2D3 in tissues not primarily related to mineral metabolism. A prime example is the hematopoietic system, where new data indicate that 1α,25(OH)2D3 may influence the function of myeloid and lymphoid cells.
KeywordsHematopoietic Cell Myeloid Leukemia Cell Line Human Promyelocytic Leukemia Cell Normal Human Bone Marrow Human Promyelocytic Leukemia Cell Line
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