Interactions of 1α,25-Dihydroxyvitamin D3 and Hematopoietic Cells

  • H. Reichel

Abstract

The biologically active metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], is recognized as a major hormonal regulator of calcium metabolism in man (Norman et al. 1982), Recently, evidence has been obtained for a wider biological role of 1α,25(OH)2D3 in tissues not primarily related to mineral metabolism. A prime example is the hematopoietic system, where new data indicate that 1α,25(OH)2D3 may influence the function of myeloid and lymphoid cells.

Keywords

Leukemia Cortisol Tuberculosis Testosterone Estradiol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abe E, Miyaura C, Sakagami H, Takeda M, Konno K, Yamazaki T, Yoshiki S, Suda T (1981) Differentiation of mouse myeloid leukemia cells induced by 1α,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 78:4990–4994PubMedCrossRefGoogle Scholar
  2. Adams JS, Gacad MA (1985) Characterization of 1α-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis. J Exp Med 161:755–765PubMedCrossRefGoogle Scholar
  3. Amento EP, Bhalla AK, Kumick JT, Kradin RL, Clemens TL, Holick SA, Holick MF, Krane SM (1984) 1α,25-Dihydroxy vitamin D3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production of the monokine mononuclear cell factor. J Clin Invest 73:731–739PubMedCrossRefGoogle Scholar
  4. Baker AR, McDonnell DP, Hughes M, Crisp TM, Mangelsdorf DJ, Haussler MR, Pike JW, Shone J, O’Malley BW (1988) Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci USA 85:3294–3298PubMedCrossRefGoogle Scholar
  5. Bar-Shavit Z, Teitelbaum SL, Reitsma P, Hall A, Pegg LE, Trial J, Kahn AJ (1983) Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 80:5907–5911PubMedCrossRefGoogle Scholar
  6. Bar-Shavit Z, Kahn AJ, Stone KR, Trial J, Hilliard T, Reitsma PH, Teitelbaum SL (1986) Reversibility of vitamin D-induced human leukemia cell maturation. Endocrinology 118 :679–686PubMedCrossRefGoogle Scholar
  7. Barbour GL, Cobum JW, Slatopolsky E, Norman AW, Horst RL (1981) Hypercalcemia in an anephric patient with sarcoidosis: evidence for extrarenal generation of 1,25-dihydroxyvitamin D3. N Engl J Med 305:440–443PubMedCrossRefGoogle Scholar
  8. Burger EH, Van der Meer JWM, Van de Gevel JS, Gribnau JC, Thesingh CW, Van Furth R (1982) In vitro formation of osteoclasts from long-term cultures of bone marrow mononuclear phagocytes. J Exp Med 156:1604–1614PubMedCrossRefGoogle Scholar
  9. Crystal RG, Bitterman PB, Rennard SI, Hance AJ, Keough BA (1984) Interstitial lung diseases of unknown cause. N Engl J Med 310:235–244PubMedCrossRefGoogle Scholar
  10. Dexter TM, Allen TD, Lajtha LG (1977) Conditions controlling the proliferation of hematopoietic stem cells in vitro. J Cell Physiol 91:335–343PubMedCrossRefGoogle Scholar
  11. Dorshkind K, Reichel H, Norman AW (in press) 1,25-Dihydroxyvitamin D3 inhibits myelopoiesis but not B-lymphopoiesis in long-term bone marrow cultures. Exp Hematol Gkonos PJGoogle Scholar
  12. London R, Hendler ED (1984) Hypercalcemia and elevated 1,25-dihydroxy vitamin D levels in a patient with end-stage renal disease and active tuberculosis. N Engl J Med 311:1683–1685PubMedCrossRefGoogle Scholar
  13. Holtrop ME, Cox KA, Clark MB, Holick MF, Anast CF (1981) 1,25-Dihydroxycholecalciferol stimulates osteoclasts in rat bones in the absence of parathyroid hormone. Endocrinology 108:2293–2301PubMedCrossRefGoogle Scholar
  14. Honma Y, Hozumi M, Abe E, Konno K, Fukushima M, Hata S, Nishii Y, DeLuca HF, Suda T (1983) 1α,25-Dihydroxyvitamin D3 and 1α-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells. Proc Natl Acad Sci USA 80:201–204PubMedCrossRefGoogle Scholar
  15. Iho S, Takahashi T, Kura F, Sugiyama H, Hoshin T (1986) The effect of 1,25-dihydroxyvitamin D3 on in vitro immunoglobulin production in human B cells. J Immunol 236:4227–4231Google Scholar
  16. Inaba M, Okuno S, Nishizawa Y, Yukioka K, Otani S, Matsui-Yuasa I, Morisawa S, DeLuca HF, Morii H (1987) Biological activity of fluorinated vitamin D analogs at C-26 and C-27 on human promyelocytic leukemia cells, HL-60. Arch Biochem Biophys 258:421–425PubMedCrossRefGoogle Scholar
  17. Koeffler HP, Armatruda T, Ikekawa N, Kobayashi Y, DeLuca HP (1984) Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues. Cancer Res 44:5624–5628PubMedGoogle Scholar
  18. Koeffler HP, Hirji K, Itri L (1985) 1,25-Dihydroxyvitamin D3: in vivo and in vitro effects on human preleukemic and leukemic cells. Cancer Treat Rep 69:1399–1406PubMedGoogle Scholar
  19. Mangelsdorf DJ, Koeffler HP, Donaldson CA, Pike JW, Haussler MR (1984) 1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60). Receptor-mediated maturation to macrophage-like cells. J Cell Biol 98:391–398PubMedCrossRefGoogle Scholar
  20. McCarthy DM, SanMiguel JF, Freake HC, Green PM, Zola H, Catovsky D, Goldman JM (1983) 1,25-Dihydroxyvitamin D3 inhibits proliferation of human promyelocytic leukaemia (HL-60) cells and induces monocyte macrophage differentiation in HL-60 and normal human bone marrow cells. Leuk Res 7:51–55PubMedCrossRefGoogle Scholar
  21. McDonnell DP, Mangelsdorf DJ, Pike JW, Haussler MR, O’Malley BW (1987) Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science 235:1214–1217PubMedCrossRefGoogle Scholar
  22. McSheehy PMJ, Chambers TJ (1987) 1,25-Dihydroxyvitamin D3 stimulates rat osteoblastic cells to release a soluble factor that increases osteoclastic bone resorption. J Clin Invest 80:425–429PubMedCrossRefGoogle Scholar
  23. Munker R, Norman AW, Koeffler HP (1986) Vitamin D compounds. Effect on clonal proliferation and differentiation of human myeloid cells. J Clin Invest 78:424–430PubMedCrossRefGoogle Scholar
  24. Murao S, Gemmell MA, Callaham MF, Anderson NL, Huberman E (1983) The control of macrophage cell differentiation in human promyelocytic HL-60 leukemia cells by 1,25-dihydroxyvitamin D3 and phorbol-12-myristate-13-acetate. Cancer Res 43:4989–4996PubMedGoogle Scholar
  25. Norman AW, Roth J, Orci L (1982) The vitamin D endocrine system: steroid metabolism, hormone receptors, and biological response (calcium binding proteins). Endocr Rev 3 :331–366PubMedCrossRefGoogle Scholar
  26. Olsson I, Gullberg U, Ivhed I, Nilsson K (1983) Induction of differentiation of the human histiocytic lymphoma cell line U937 by 1α,25-dihydroxycholecalciferol. Cancer Res 43:5862–5867PubMedGoogle Scholar
  27. Prowedini DM, Tsoukas KD, Deftos LJ, Manolagas SC (1983) 1,25-Dihydroxyvitamin D3 receptors in human leukocytes. Science 221:1181–1183CrossRefGoogle Scholar
  28. Reichel H, Koeffler HP, Tobler A, Norman AW (1987a) 1α,25-Dihydroxy vitamin D3 inhibits interferon-γ synthesis by normal human peripheral blood lymphocytes. Proc Natl Acad Sci USA 84:3385–3389PubMedCrossRefGoogle Scholar
  29. Reichel H, Koeffler HP, Norman AW (1987b) Synthesis in vitro of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 by interferon-γ stimulated normal human bone marrow and alveolar macrophages. J Biol Chem 262:10931–10937PubMedGoogle Scholar
  30. Reichel H, Koeffler HP, Barbers R, Norman AW (1987c) Regulation of 1,25-dihydroxyvitamin D3 production by cultured alveolar macrophages from normal human donors and from patients with pulmonary sarcoidosis. J Clin Endocr Metab 65:1201–1209PubMedCrossRefGoogle Scholar
  31. Rigby WFC, Stacy T, Fanger MW (1984a) Inhibition of T-lymphocyte mitogenesis by 1,25- dihydroxyvitamin D3 (calcitriol). J Clin Invest 74:1451–1455PubMedCrossRefGoogle Scholar
  32. Rigby WFC, Shen L, Bal ED, Guyre PM, Fanger MW (1984b) Differentiation of a human monocytic cell line by 1,25-dihydroxyvitamin D3 (calcitriol): a morphologic, phenotypic, and functional analysis. Blood 64:1110–1115PubMedGoogle Scholar
  33. Roodman GD, Ibbotson KJ, MacDonald BR, Kuehl TJ, Mundy GR (1985) 1,25-Dihydroxyvitamin D3 causes formation of multinucleated cells with several osteoclast characteristics in cultures of primate marrow. Proc Natl Acad Sci USA 82:8213–8217PubMedCrossRefGoogle Scholar
  34. Tanaka H, Abe E, Miyaura C, Kuribayashi T, Konno K, Nishii, Suda T (1982) 1,25-Dihydroxycholecalciferol and a human myeloid leukemia cell line (HL-60). The presence of a cytosol receptor and induction of differentiation. Biochem J 204:713–719PubMedGoogle Scholar
  35. Tobler A, Gasson J, Reichel H, Norman AW, Koeffler HP (1987) Granulocyte-macrophage colony-stimulating factor: sensitive and receptor-mediated regulation by 1,25-dihydroxyvitamin D3 in normal human peripheral blood lymphocytes. J Clin Invest 79:1700–1705PubMedCrossRefGoogle Scholar
  36. Tobler A, Miller CW, Norman AW, Koeffler HP (1988) 1,25-Dihydroxyvitamin D3 modulates the expression of a lymphokine (granulocyte-macrophage colony-stimulating factor) post- transcriptionally. J Clin Invest 81:1819–1823PubMedCrossRefGoogle Scholar
  37. Whitlock CA, Witte ON (1982) Long-term culture of B lymphocytes and their precursors from murine bone marrow. Proc Natl Acad Sci USA 79:3608–3612PubMedCrossRefGoogle Scholar
  38. Yoshida M, Ishizuka S, Hoshi A (1984) Biological activity of vitamin D derivatives in inducing differentiation of HL-60 human promyelocytic leukemia cells. J Pharmacobiodyn 7:962–968PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. Reichel

There are no affiliations available

Personalised recommendations