Classification of New Cases: Some Aspects of Single and Multivariate Analysis
In the preceding chapters we have discussed the advantages of quantitation, the factors which influence the subjective diagnostic process and the implicit or subconscious presence of a structural model in the qualitative or quantitative analysis of a structure. Chapter 3 and sections A.2.1 and A.2.2 deal with the collection of quantitative data. In the present chapter, some aspects of techniques used for the discrimination of groups of patients on the basis of quantitative data will be discussed. Moreover, the classification of new patients will be considered. In agreement with the aims of this manual, and as we hope, also in accordance with the desire of most of the readers, formulas will be omitted as much as possible. Diagrams will illustrate the purposes of certain techniques. For a more technical, mathematical-oriented approach, reference is made to basic statistical textbooks (Cooley and Lohnes, 1971; Meisel, 1972). Of course, the criteria to define the groups to be investigated should be very clearly defined beforehand, irrespective of the nature of the criteria (morphological, biochemical, prognostic, or other).
Unable to display preview. Download preview PDF.
- Baak, J.P.A. and Bezemer, P.D. (1974). Discriminant analysis of stereological parameters in normals and SIDS. In: Quantitative analysis of microstructures in medicine, H.E. Exner, editor, Riederer, Stuttgart, pp. 113–123.Google Scholar
- Baak, J.P.A., Diegenbach, P.C., Kurver, P.H.J., Stolk, J.G., Harten, J.J. van der (1979). An example of quantitative microscopy in individual patient care. Mikroskopie 37:305–307.Google Scholar
- Baak, J.P.A., Agrafojo Blanco, A., Kurver, P.H.J., Langley, F.A., Boon, M.E., Lindeman, J. and Diegenbach, P.C. (1981). Quantitation of borderline and malignant mucinous ovarian tumours. Histo-pathology 5, 353–360.Google Scholar
- Boon, M.E., Loewhagen, T., Lopes Cardozo, P., Blonk, D.I., Kurver, P.H.J, and Baak, J.P.A. (1982 b). Computation of pre-operative diagnosis probability for follicular adenoma and carcinoma of the thyroid on aspiration smears. Quant. Anal. Cytol. 4, 1–5.Google Scholar
- Carpenter, R.G. and Emery, J.L. (1974). The identification and follow-up of high risk infants. In: Sudden infant death syndrome, R.R. Robinson, editor, London and Toronto, Foundation for the study of infant death, pp. 91–96.Google Scholar
- Cooley, W.W. and Lohnes, P.R. (1971). Multivariate data analysis. John Wiley and Sons Inc., New York.Google Scholar
- Galen, R.S. and Gambino, S.R. (1975). Beyond normality: the predictive value and efficiency of medical diagnoses. John Wiley and Sons Inc., New York, pp. 10–14.Google Scholar
- Hermans J. and Habbema J.D.F. (1975). Comparison of five methods to estimate posterior probabilities. EDV in Medizin und Biologie 1, 14–19.Google Scholar
- Meisel, W.S. (1972). Computer-oriented approaches to pattern recognition. Mathematics in science and engineering, vol. 83, Academic Press, New York.Google Scholar