Abstract
The concept of prophylactic and adjuvant regional chemotherapy of the liver in colorectal malignancies is based on the fact that 25%–30% of the patients already have linear metastases at the time of primary resection. Of those without metastases at this time, 40%–50% develop liver metastases secondarily [2,8]. In view of this, Taylor perfused the liver via the recanalized umbilical vein with 1 g 5-fiuorouracil (5-FU) per day continuously for 7 days, starting immediately after curative resection of the tumor. He observed fewer liver metastases and better survival in the perfusion group [11].
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© 1990 Springer-Verlag Berlin Heidelberg
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Gruenagel, H.H., Molzahn, E., Neumann, S., Neukamp, GU. (1990). Prophylactic and Adjuvant Regional Chemotherapy of the Liver in Colorectal Malignancies. In: Jakesz, R., Rainer, H. (eds) Progress in Regional Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74818-9_6
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DOI: https://doi.org/10.1007/978-3-642-74818-9_6
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