Clinical and Histopathological Aspects of Hyperthermic Isolated Regional Perfusion of Soft Tissue Sarcomas of the Extremities

  • H. J. Hoekstra
  • W. M. Molenaar
  • H. Schraffordt Koops
  • J. Oldhoff
Conference paper


The treatment of a soft tissue sarcoma (STS) of an extremity depends on the location and size of the tumor, the histological diagnosis and tumor grade, the tumor stage, and the previous therapy. Limb salvage and prevention of local recurrence are the two major considerations in the treatment of a malignant STS of an extremity. After inadequate therapy, there is a grave risk of local recurrence, which generally occurs within two years [16]. This is why “unresectable” STS of an extremity have been treated preferably by amputation of the limb. Hyperthermic isolated regional perfusion was introduced into the treatment of STS of the extremity with the idea of increasing the resectability rate without increasing the risk of local recurrence [9]. The rationale of combined modality therapy is that with hyperthermic isolated regional perfusion the tumor and adjacent tissue can be treated with high doses of chemotherapeutic agents and that hyperthermia enhances the sensitivity of tumor cells to chemotherapy [3, 4, 19].


Soft Tissue Sarcoma Limb Salvage Regional Perfusion Combine Modality Therapy Clear Cell Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. J. Hoekstra
    • 1
  • W. M. Molenaar
    • 1
  • H. Schraffordt Koops
    • 1
  • J. Oldhoff
    • 1
  1. 1.Division of Surgical OncologyGroningen University HospitalGroningenThe Netherlands

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