Abstract
Regional isolation perfusion of the limbs is now becoming a standard procedure worldwide. Its advantage is that a high dose of cytostatic drug can be administered to an isolated tumor-bearing region, localizing and enhancing the therapeutic effect without producing the generalized toxicity typical of systemic chemotherapy. The disadvantages of such intrasurgical chemotherapy are that the duration and frequency of drug administration are limited for technical reasons. In other words, the theory of “fractionation and protraction” [7], increasing the difference in tolerance between malignant and normal cells, is difficult to realize.
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References
Baas PC, Schraffordt Koops H, Hoekstra HJ, Oosterhuis JW, Van der Weele LT, Oldhoff J (1988) Isolated regional perfusion in the treatment of local recurrence, satellitosis and in-transit metastases of melanomas of the extremities. Reg Cancer Treat 1:33–36
Karakousis CP, Kanter PM, Park HC, Sharma SD, Moore R, Ewing JH (1982) Tourniquet infusion versus hyperthermic perfusion. Cancer 49:850–858
Kroon BBR, WiebeDink J, Benckhuijsen C et al. (1986) Regional perfusion chemotherapy, sect VIII. 3rd annual report of the Netherlands Cancer Institute, Amsterdam
Kroon BBR, Van Geel AN, Benckhuijsen C, Wieberdink J (1987) Normothermic isolation perfusion with melphalan for advanced melanoma of the limbs. Anticancer Res 7:441–442
Vaglini M, Bacci G, Baldini M, Belli F, Cascinelli N, Nava M, Picci P, Santinami M, Campanacci M (1987) Limb salvage in osteogenic sarcoma of extremities: a new therapeutic approach associating infusion and hyperthermic antiblastic perfusion. J Extra Corp Technol 19:338–347
Van Geel AN, Van der Zeel J, Wieberdink J, Kroon BBR (1985) Isolated hyperthermic perfusion of the extremity (abstract). In: ICRCT 85, Giessen, p 142
Wieberdink J (1986) Extracorporeal circulation in regional treatment of cancer. Monograph available on request from the Dutch Society of Extracorporeal Circulation, Langegeer 273, 3075 JJ Rotterdam
Wieberdink J, Benckhuijsen C, Braat RP, Van Slooten EA, Olthuis GAA (1982) Dosimetry in isolation perfusion of the limbs by assessment of perfused tissue volume and grading of toxic tissue reactions. Eur J Cancer Clin Oncol 18:905–910
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© 1990 Springer-Verlag Berlin Heidelberg
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Kroon, B.B.R., van Geel, A.N., Franklin, H.R., Klaase, J.M., Benckhuijsen, C. (1990). Preliminary Results of a Double Perfusion Schedule with Melphalan in Measurable Melanoma. In: Jakesz, R., Rainer, H. (eds) Progress in Regional Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74818-9_32
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DOI: https://doi.org/10.1007/978-3-642-74818-9_32
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