Abstract
In treating large and histologically aggressive sarcomas mutilating surgery, often requiring radical amputation became standard practice because of a high risk of local recurrence after less radical surgery. However, in spite of radical local surgery, many patients with sarcomas still developed distant metastatic disease, so that less radical approaches have been investigated for control of local tumour, at least until the period of greatest risk of metastatic disease becoming manifest has passed. Cade [1] used radical local radiotherapy for this purpose, and if after 6 months there was no evidence of metastatic disease, he then proceeded to amputation. In this way, amputation was only carried out in those patients most likely to be cured by the procedure.
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© 1990 Springer-Verlag Berlin Heidelberg
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Stephens, F.O., Marsden, W., Tattersall, M.H.N. (1990). Regional Induction Chemotherapy Followed by Radiotherapy and/or Surgery in Management of Large and Aggressive Sarcomas in Shoulder, Pelvis and Limbs. In: Jakesz, R., Rainer, H. (eds) Progress in Regional Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74818-9_27
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DOI: https://doi.org/10.1007/978-3-642-74818-9_27
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