Regional Induction Chemotherapy Followed by Radiotherapy and/or Surgery in Management of Large and Aggressive Sarcomas in Shoulder, Pelvis and Limbs

  • F. O. Stephens
  • W. Marsden
  • M. H. N. Tattersall


In treating large and histologically aggressive sarcomas mutilating surgery, often requiring radical amputation became standard practice because of a high risk of local recurrence after less radical surgery. However, in spite of radical local surgery, many patients with sarcomas still developed distant metastatic disease, so that less radical approaches have been investigated for control of local tumour, at least until the period of greatest risk of metastatic disease becoming manifest has passed. Cade [1] used radical local radiotherapy for this purpose, and if after 6 months there was no evidence of metastatic disease, he then proceeded to amputation. In this way, amputation was only carried out in those patients most likely to be cured by the procedure.


Soft Tissue Sarcoma Pulmonary Metastasis Malignant Fibrous Histiocytoma Continuous Regimen Spindle Cell Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • F. O. Stephens
    • 1
  • W. Marsden
    • 1
  • M. H. N. Tattersall
    • 1
  1. 1.Department of SurgeryUniversity of SydneySydneyAustralia

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