Abstract
Malignant liver tumors are vascularized primarily by the hepatic artery [1, 3]. Therapeutic approaches to nonresectable liver malignancies have therefore aimed at the arterial administration of cytostatic drugs to get a high therapeutic index. The systemic adverse effects of substances with a low hepatic clearance were diminished by a simultaneously reduced arterial hepatic blood flow [4].
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References
Ackerman NB, Lien WM, Kondi ES, Silverman NA (1969) The blood supply of experimental liver metastases I: The distribution of hepatic arterial and portal vein blood to “small” and “large” tumors. Surgery 66:1067
Aronsen KF, Hellekant C, Holmberg J (1979) Controlled blocking of hepatic artery flow with enzymatically degradable microspheres combined with oncolytic drugs. Eur Surg Res 11:99
Breedis C, Young G (1954) The blood supply of neoplasms in the liver. Am J Pathol 30:969–986
Chen HSG, Gross JF (1980) Intra-arterial infusion of anticancer drugs: theoretic aspects of drug delivery and review of responses. Cancer Treat Rep 64:31–40
Dakhil S, Ensminger W, Cho K, Niederhuber J, Doan K, Wheeler R (1982) Improved regional selectivity of hepatic arterial BCNU with degradable microspheres. Cancer 50:631–635
Gyves JW, Ensminger WD, Van Harken D, Niederhuber J, Stetson P, Walker S (1983) Improved regional selectivity of hepatic arterial mitomycin by starch microspheres. Clin Pharmacol Ther 34:259–265
Lindell BO, Aronsen KF, Nosslin B et al. (1978) Studies in pharmacokinetics and tolerance of substances temporarily retained in the liver by starch microsphere embolization. Ann Surg 187:95–99
Miller AA, Schmidt CG (1987) Clinical pharmacology and toxicity of 4′-o-tetrahydropyranyladriamycin. Cancer Res 47:1461–1465
Rothman U, Arfors KE, Aronsen KF, Lindell B, Nylander G (1976) Enzymatically degradable microspheres for experimental and clinical use. Microvasc Res 11:421
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© 1990 Springer-Verlag Berlin Heidelberg
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Burk, M., Schoppe, W.D., Miller, A.A., Jungblut, R.M., Schneider, W. (1990). Dextrane Particle Use in Regional Chemotherapy: Problems of Monitoring. In: Jakesz, R., Rainer, H. (eds) Progress in Regional Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74818-9_18
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DOI: https://doi.org/10.1007/978-3-642-74818-9_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74820-2
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