Abstract
The liver is the first and most frequent site of metastasis of gastroenteric cancer; in 10% of cases such pathology is already present at the time of diagnosis of the primary neoplasm. Metachronous metastases occur within 5 years in 20% of patients. The average survival in the case of untreated liver metastases from large bowel cancer is 6–8 months; 30%–35% of such patients are alive after 6 months and only 15%–18% at 1 year [1,5]. The therapy of liver metastases is based on surgical resection, systemic chemotherapy, and radiotherapy, but response rates are not good. Surgery is indicated only when the liver presents a single metastasis or multiple metastases confined to one lobe; this is the case in 20%–25% of patients, and no more than 5%– 10% cases are actually operable. Chemotherapy is indicated in all other patients, and because systemic treatment is ineffective many groups throughout the world have been using locoregional intra-arterial therapy [6, 9].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Wallace S, Chuang VP (1982) Transcatheter management of the cancer patient. In: De Vita V (ed) Cancer principles and practise of oncology. Lippincott Philadelphia, pp 1862–1877
Gennari L, Doli R, Orefice S et al. (1982) Trattamento infusionale locoregionale dei tumori primitivi e metastatici del fegato. Meeting multidisciplinare su: “Tecniche speciali di somministrazione di farmaci antiblastici”, Verona, 15 Oct 1982
Lokich J et al. (1981) Concomitant hepatic radiation and intraarterial fluorinated pyrimidine therapy. Cancer 48:2569–2574
Friedman M et al. (1979) Combined modality therapy of hepatic metastasis. Cancer 44:906–913
Ramming KP, Sporks FC, Eilber FR et al. (1979) Il trattamento delle metastasi epatiche. Aggiorn Oncol Clin V(4): 323–341
Oberfield RA (1979) Prolonged and continuous percutaneous intraarterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary. Cancer 44:414–423
Ansfield FJ, Ramirez G, Davis HL et al. (1971) Further clinical studies with intrahepatic arterial infusion with 5-FU. Cancer 36:2413–2417
Ansfield FJ, Ramirez G et al. (1971) Intrahepatic arterial infusion with 5FU. Cancer 28:1147–1151
Cady B, Oberfield RA (1974) Regional infusion chemotherapy of hepatic metastases from carcinoma of the colon. Am J Surg 127:220–227
Sturba F, Bonsignori M, Rossi G et al. (1984) Chemioterapia infusionale intraepatica per via percutanea delle metastasi epatiche da neoplasie del tratto gastro-enterico. Paper presented at congress “Terapie d’avanguardia in oncologia”, Ancona, 28–29 Sept 1984
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sturba, F. et al. (1990). Intra-arterial Chemotherapy of Liver Metastases. In: Jakesz, R., Rainer, H. (eds) Progress in Regional Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74818-9_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-74818-9_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74820-2
Online ISBN: 978-3-642-74818-9
eBook Packages: Springer Book Archive