Regional Therapy with 5-Fluorouracil: Dependence of Systemic Concentrations on the Infusion Rate

  • A. Schalhorn
  • G. Peyerl
  • W. Heinlein
  • W. Wilmanns
Conference paper

Abstract

Hepatic artery infusion (HAI) with floxuridine (FUDR) has resulted in CT-confirmed remission rates between 30% and 50% in patients with liver metastases from colorectal cancer [5]. In spite of very optimistic reports, especially that by Balch and Urist [1], long-term results are less impressive. There is a relatively high risk of local toxicity due to chemical hepatitis and/or sclerosing cholangitis [3]. A high proportion of the patients will eventually develop extrahepatic metastases, and no statistically significant survival advantage for patients treated by HAI with FUDR has yet been demonstrated [4,6].

Keywords

Toxicity Catheter HPLC Hepatitis Oncol 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • A. Schalhorn
    • 1
  • G. Peyerl
    • 1
  • W. Heinlein
    • 1
  • W. Wilmanns
    • 1
  1. 1.Medizinische Klinik IIIKlinikum Großhadern, Ludwig Maximilian-UniversitätMünchen 70Germany

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