Skip to main content
SpringerLink
Log in

Neurologische Manifestationen

  • Conference paper
Frauen und AIDS

  • 39 Accesses

Zusammenfassung

Zwei Jahre nach Gottliebs Erstbeschreibung (1981) des erworbenen Immundefektsyndroms (AIDS) berichteten Snider et al. (1983) über neurologische Komplikationen bei 50 AIDS-Patienten. Dem folgten zahllose Einzelfalldarstellungen wie auch mehrere Untersuchungen an größeren Kollektiven, wovon insbesondere die Arbeiten von Levy et al. (1985) sowie Enzensberger u. Fischer (1987) zu erwähnen sind.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Ackermann R, Nekic M, Jürgens R (1986) Locally synthesized antibodies in cerebrospinal fluid of patients with AIDS. J Neurol 233: 140–141

    Article  PubMed  CAS  Google Scholar 

  • Albert ML, Feldmann RG, Willis AL (1974) The „subcortical dementia“ of progressive supra-nuclear palsy. J Neurol Neurosurg Psychiatry 37: 121–130

    Article  PubMed  CAS  Google Scholar 

  • Appleman ME, Marshall DW, Brey RL et al. (1988) Cerebrospinal fluid abnormalities in pa-tients without AIDS who are seropositive for the human immunodeficiency virus. J Infect Dis 158: 193–199

    Article  PubMed  CAS  Google Scholar 

  • Barnes DM (1987) Solo action of AIDS virus coat. Science 237: 971–973

    Article  PubMed  CAS  Google Scholar 

  • Bennett JE, Dismukes WE, Duma RJ et al. (1979) A comparison of amphotericine B alone and combined with flucytosine in the treatment of cryptococcal meningitis. N Engl J Med 301: 126–131

    Article  PubMed  CAS  Google Scholar 

  • Berger JR, Kaszovitz B, Post JD, Dickinson G (1987) Progressive multifocal leukoencephalo-pathy associated with human immunodeficiency virus infection. Ann Int Med 107: 78–87

    PubMed  CAS  Google Scholar 

  • Berger JR, Moskowitz L, Fischl M, Kelley RE (1987) Neurologic disease as the presenting manifestation of acquired immunodeficiency syndrome. South Med J 80: 683–686

    Article  PubMed  CAS  Google Scholar 

  • Bessen LJ, Greene JF, Louie E, Seitzman P, Weinberg H (1988) Severe polymyositis-like syndrome associated with zidovudine therapy of AIDS and ARC. N Engl J Med 318: 708

    PubMed  CAS  Google Scholar 

  • Biniek R, Bartholome M, Schulz M, Lehmann HJ, Gesemann H, Scheiermann N (1988) Intrathecal production of HIV antibodies in suspected AIDS encephalopathy. J Neurol 235: 131–135

    Article  PubMed  CAS  Google Scholar 

  • Bredesen DE, Levy RM, Rosenblum ML (1988) The neurology of human immunodeficiency virus infection. Quart J Med 68: 665–677

    PubMed  CAS  Google Scholar 

  • Budka H, Constanzi G, Cristina S, Lechi A, Parravicini C, Trabattoni R, Vago L (1987) Brain pathology induced by infection with the human immunodeficiency virus ( HIV ). Acta Neuro-pathol 75: 185–198

    Google Scholar 

  • Carne CA, Tedder RS, Smith A et al. (1985) Acute encephalopathy coincident with seroconversion for anti-HTLV-III. Lancet II: 1206–1208

    Google Scholar 

  • Centers for Disease Control, Atlanta (1987) Re-vision of the CDC surveillance case definition for acquired immunodeficiency syndrome. MMW36 [Suppl 1]: 1 — 15

    Google Scholar 

  • Chiodi F, Norkrans G, Hagberg L et al. (1988) Human immunodeficiency virus infection of the brain. II. Detection of intrathecally synthesized antibodies by enzyme linked immunosorbent assay and imprint immunofixation. J Neurol Sei 87: 37–48

    Google Scholar 

  • Cornblath DR (1988) Treatment of the neuromuscular complications of human immunodeficiency virus infection. Ann Neurol 23 [Suppl]: 88 — 91

    Article  Google Scholar 

  • Diederich NA, Karenberg A, Peters UH (1988) Psychopathologische Bilder bei der HIV-Infektion: AIDS-Lethargie und AIDS-Demenz. Fortschr Neurol Psychiatr 56: 173–185

    Google Scholar 

  • Drew WL (1988) Cytomegalovirus infection in patients with AIDS. J Infect Dis 158: 449–456

    Article  PubMed  CAS  Google Scholar 

  • Einhäupl KM, Pfister HW, Matuschke A et al. (1988) Die Bedeutung verschiedener Liquorsyndrome und neurologischer Befunde für die Diagnose der HIV-Enzephalopathie. Vortrag auf dem I. Deutschen AIDS-Kongreß, München 1988

    Google Scholar 

  • Elovaara I, Seppälä I, Poutiainen E, Suni J, Valle SL (1988) Intrathecal humoral immunologic response in neurologically symptomatic and asymptomatic patients with human immuno-deficiency virus infection. Neurology 308: 1451–1456

    Google Scholar 

  • Engstrom J, Lowenstein DH, Bredesen DE (1988) Stroke and transient neurologic deficits associated with AIDS. Neurology (American Academy of Neurology Newsletter) 1988

    Google Scholar 

  • Enzensberger W, Fischer PA (1987) Zentralner-vöse Befunde bei 140 Frankfurter Patienten mit HIV-Infektion. In: Fischer PA, Schlote W (Hrsg) AIDS und Nervensystem. Springer, Berlin Heidelberg New York Tokyo, S 54–63

    Google Scholar 

  • Enzensberger W, Fischer PA (1987) Neurological complications in AIDS. J Neurol 234: 269–279

    Article  PubMed  Google Scholar 

  • Goudsmit E, Wolters EC, Bakker M et al. (1986) Intrathecal synthesis of antibodies to HTLV-III in patients without AIDS or AIDS related complex. Br Med J 292: 1231–1234

    Article  CAS  Google Scholar 

  • Fenton TW (1987) AIDS-related psychiatric disorder. Br J Psychiatry 151: 579–588

    Article  PubMed  CAS  Google Scholar 

  • Goethe KE, Mitchell JE, Marshall DW et al. (1989) Neuropsychological and neurological function of human immunodeficiency virus se-ropositive asymptomatic individuals. Arch Neurol 46: 129–133

    PubMed  CAS  Google Scholar 

  • Gold JE, Jimenez E, Zalusky R (1988) Human immunodeficiency virus-related lymphoreticu-lar malignancies and peripheral neurologic disease. Cancer 61: 2318–2324

    Article  PubMed  CAS  Google Scholar 

  • Gorard DA, Henry K, Guiloff RF (1988) Necro-tising myopathy and zidovudine. Lancet 1: 1050

    Article  Google Scholar 

  • Gottlieb MS, Schroff R, Schanker HM, Weisman JD, Fan PT, Wolf RA, Saxon A (1981) Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. N Engl J Med 305: 1425–1431

    Article  PubMed  CAS  Google Scholar 

  • Goudsmit J, de Wolf F, Paul DA et al. (1986) Expression of human immunodeficiency virus antigen ( HIV-Ag) in serum and cerebrospinal fluid during acute and chronic infection. Lancet 11: 177–180

    Google Scholar 

  • Gray F, Gherardi R, Scaravilli F (1988) The neu-ropathology of the acquired immune deficiency syndrome ( AIDS ). Brain 111: 245–266

    Google Scholar 

  • Härtung HP, Heininger K, Toyka KV (1988) Neuromuskuläre Manifestationen der HIV–1-und HTLV-I-Infektionen. Dtsch Med Wo-chenschr 113: 1975–1981

    Article  Google Scholar 

  • Haverkos TE and the TE Study Group (1987) Assessment of therapy for toxoplasma encephalitis. Am J Med 82: 907–914

    Article  PubMed  CAS  Google Scholar 

  • Heibert M, Robinson D, Peddle B, Mann J, Gore D, Stoneham C, Pinching A (1988) Treatment of patients with AIDS and AIDS-related complex with zidovudine. IVth International Conference on AIDS. Stockholm 1988

    Google Scholar 

  • Helweg-Larsen S, Jakobsen J, Boesen F et al. (1988) Myelopathy in AIDS. A clinical and electrophysiological study of 23 Danish patients. Acta Neurol Scand 77: 64–73

    Article  PubMed  CAS  Google Scholar 

  • Hicks CB, Benson PM, Lupton GP, Tramont EC (1987) Seronegative secondary syphilis in a patient infected with the human immunodeficiency virus ( HIV) with Kaposi sarcoma. Ann Int Med 107: 492–495

    Google Scholar 

  • Ho DD, Rota RT, Schooley RT et al. (1985) Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N Engl J Med 313: 1493–1497

    Article  PubMed  CAS  Google Scholar 

  • Ho DD, Pomerantz RJ, Kaplan JC (1987) Pathogenesis of infection with human immunodeficiency virus. N Engl J Med 317: 278–286

    Article  PubMed  CAS  Google Scholar 

  • Hollander H, Levy JA (1987) Neurological abnormalities and recovery of human immunodeficiency virus from cerebrospinal fluid. Ann Int Med 106: 692–695

    PubMed  CAS  Google Scholar 

  • Hollander H, Stringari S (1987) Human immunodeficiency virus-associated meningitis. Am J Med 83: 813–816

    Article  PubMed  CAS  Google Scholar 

  • Israelski DM, Tom C, Remington JS (1989) Zidovudine antagonizes the action of pyrimethamine in experimental infection with toxoplasma gondii. Antimicrob Agent Chemother 33: 30–34

    CAS  Google Scholar 

  • Jacome DE (1982) Neurogenic bladder, lumbo-sacral plexus neuropathy and drug-associated rhabdomyolysis. J Urol 127: 994–995

    PubMed  CAS  Google Scholar 

  • Klecker RW, Collins JM, Yarchoan R, Thomas R, Jenkins JF, Broder S, Myers CE (1987) Plasma and cerebrospinal fluid pharmacokinetic of 3′-azido–3′-deoxythimidine: A novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases. Clin Pharmacol Ther 41: 407–412

    Google Scholar 

  • Koenig S, Gendelman HE, Orenstein JM et al. (1986) Detection of AIDS virus in macropha-ges in brain tissue from AIDS patients with en-cephalopathy. Science 233: 1089–1093

    Article  PubMed  CAS  Google Scholar 

  • Kovacs JA, Kovacs AA, Polis M et al. (1985) Cryptococcosis in the acquired immunodefi-ciency syndrome. Ann Int Med 103: 533 — 538

    PubMed  CAS  Google Scholar 

  • Lange DJ, Britton CB, Younger DS, Hay AP (1988) The neuromuscular manifestations of human immunodeficiency virus infections. Arch Neurol 45: 1084–1088

    PubMed  CAS  Google Scholar 

  • Levy JA, Shimabukuro J, Hollander H, Mills J, Kaminsky L (1985) Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms. Lancet 11: 586–588

    Google Scholar 

  • Levy RM, Bredesen DE, Rosenblum ML (1985) Neurological manifestations of the acquired immunodeficiency syndrome: Experience at UCSF and review of the literature. J Neurosurg 62: 475–495

    Google Scholar 

  • Lohmöller G, Matuschke A, Goebel FD (1988) Autonome Neuropathie bei HIV-Infektion? I. Deutscher AIDS-Kongreß, München 1988 Lüer W, Poser S, Weber T, Jürgens S, Eichenlaub D, Pohle HD, Felgenhauer K (1988)

    Google Scholar 

  • Chronic HIV-encephalitis — I. Cerebrospinal fluid diagnosis. Klin Wochenschr 66: 21 — 28

    Google Scholar 

  • Maccario M, Scharre D (1987) HIV and acute on-set of psychosis. Lancet 11: 342

    Article  Google Scholar 

  • Marshall DW, Brey RL, Cahill WT, Houk RW, Zajac RA, Boswell RN (1988) Spectrum of cerebrospinal fluid findings in various stages of human immunodeficency virus infection. Arch Neurol 45: 954–958

    PubMed  CAS  Google Scholar 

  • Matthes J, Walker LA, Watson JG, Bird AG (1988) AIDS encephalopathy with response to treatment. Arch Dis Child 63: 545–547

    Article  PubMed  CAS  Google Scholar 

  • Miller RF, Semple SJG (1987) Autonomic neuropathy in AIDS. Lancet 11: 343–344

    Article  Google Scholar 

  • Mizusawa H, Hirano A, Llena JF, Shintaku M (1988) Cerebrovascular lesions in acquired im-munodeficiency syndrome ( AIDS ). Acta Neu-ropathol 76: 451–457

    Google Scholar 

  • Möller AA, Jäger H, Bremer D (1988) Paranoide Psychosen bei HIV-Infektion. Dtsch Med Wo-chenschr 113: 1234–1235

    Article  Google Scholar 

  • Monte de la SM, Ho DD, Schooley RT, Hirsch MS, Richardson EP (1987) Subacute encephalomyelitis of AIDS and its relation to HTLV-III infection. Neurology 37: 562–569

    Google Scholar 

  • Morgello S, Chos ES, Nielsen S, Devinsky O, Petita CK (1987) Cytomegalovirus encephalitis in patients with acquired immunodeficiency syndrome: An autopsy study of 30 cases and a review of the literature. Hum Pathol 18: 289–297

    Article  PubMed  CAS  Google Scholar 

  • Naber D, Perro C, SchickU et al. (1989) Psychiatrische Symptome und neuropsychologische Auffälligkeiten bei HIV-Infizierten. Nervenarzt 60: 80–85

    PubMed  CAS  Google Scholar 

  • Navia BA, Jordan BD, Price RW (1986) The AIDS dementia complex: I. Clinical features. Ann Neurol 19: 517–524

    Google Scholar 

  • Navia BA, Petito CK, Gold JWM, Cho ES, Jordan BD, Price RW (1986) Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: Clinical and neuropatho-logical findings in 27 patients. Ann Neurol 19: 224–238

    Article  PubMed  CAS  Google Scholar 

  • Newsome DA, Green WR, Miller ED, Kiessling LA, Morgan B, Jabs DA, Polk BF (1984) Microvascular aspects of acquired immune deficiency syndrome retinopathy. Am J Ophthalmol 98: 590–601

    PubMed  CAS  Google Scholar 

  • Petito CK, Navia BA, Cho ES, Jordan BD, George DC, Price RW (1985) Vacuolar myelopathy pathologically resembling subacute combined degeneration in patients with the acquired immunodeficiency syndrome. N Engl J Med 312: 874–879

    Article  PubMed  CAS  Google Scholar 

  • Pfister HW, Einhäupl KM, Büttner U, Goebel FD, Matuschke A, Schielke E, Fröschl M (1989) Dissociated nystagmus as a common sign of oculomotor disorders in HIV infected patients. Eur Neurol (in press)

    Google Scholar 

  • Pizzo PA, Eddy J, Falloon J et al. (1988) Effect of continuous intravenous infusion of zidovudine in children with symptomatic HIV infection. N Engl J Med 319: 889–896

    Article  PubMed  CAS  Google Scholar 

  • Pohl P, Vogl G, Fill H, Rössler H, Zangerle R, Gerstenbrand F (1988) Single photon emission computed tomography in AIDS dementia complex. J Nucl Med 29: 1382–1386

    PubMed  CAS  Google Scholar 

  • Post MJD, Kursunoglu SJ, Hensley GT, Chan JC, Moskowitz LB, Hoffman TA (1985) Cranial CT in acquired immunodeficiency syndrome: Spectrum of diseases and optimal contrast enhancement technique. AJR 145: 929–940

    Google Scholar 

  • Poutiainen E, Iivanainen M, Elovaara I, Valle SL, Lähdevirta J (1988) Cognitive changes as early signs of HIV infection. Acta Neurol Scand 78: 49–52

    Article  PubMed  CAS  Google Scholar 

  • Price RW, Brew BJ (1988) The AIDS dementia complex. J Infect Dis 158:1079–1083 Przedborski S, Liesnard C, Voordecker P et al. (1988) Inflammatory demyelinating polyradi-culoneuropathy associated with human immu-nodeficiency virus infection. J Neurol 235: 359–361

    Google Scholar 

  • Pumarola-Sune T, Navia BA, Cordon-Cardo C, Cho ES, Price RW (1987) HIV antigen in the brains of patients with the AIDS dementia complex. Ann Neurol 21: 490–496

    Article  PubMed  CAS  Google Scholar 

  • Resnick L, di Marzo-Veronese F, Schüpback J et al. (1985) Intra-blood-brain-barrier synthesis of HTLV-III-specific IgG in patients with neurologic symptoms associated with AIDS or AIDS-related complex. N Engl J Med 313: 1498–1504

    Article  PubMed  CAS  Google Scholar 

  • Resnick L, Berger JR, Shapshak P, Tourtellotte WW (1988) Early penetration of the blood-brain-barrier by HIV. Neurology 38:9–14 Rosenblum LM, Levy RM, Bredesen DE, So YT, Wara W, Ziegler JL (1988) Primary central nervous system lymphomas in patients with AIDS. Ann Neurol 23 [Suppl]: 13–16

    Article  Google Scholar 

  • Schielke E, Pfister HW, Einhäupl KM (1989) Peripheral facial nerve palsy associated with HIV infection. Lancet 1: 553–554

    Article  PubMed  CAS  Google Scholar 

  • Schmitt FA, Bigley JW, McKinnis R, Logue PE, Evans RW, Drucker JL (1988) Neuropsychological outcome of zidovudine ( AZT) treatment of patients with AIDS and AIDS-related complex. N Engl J Med 319: 1573–1578

    Google Scholar 

  • Shaw GM, Harper ME, Hahn BH et al. (1985) HTLV-III infection in brains of children and adults with encephalopathy. Science 227: 177–182

    Article  PubMed  CAS  Google Scholar 

  • Smith T, Jakobsen J, Gaub J, Helweg-Larsen S, Trojaborg W (1988) Clinical and electrophy-siological studies of human immunodeficiency virus-seropositive men without AIDS. Ann Neurol 23: 295–297

    Article  PubMed  CAS  Google Scholar 

  • Snider WD, Simpson DM, Nielsen S, Gold J, Metroka CE, Posner JB (1983) Neurological complications of acquired immune deficiency syn-drome: Analysis of 50 patients. Ann Neurol 14: 403–418

    Article  PubMed  CAS  Google Scholar 

  • Simpson DM, Bender AN (1988) Human immunodeficiency virus-associated myopathy: Analysis of 11 patients. Ann Neurol 24: 79–84

    Article  PubMed  CAS  Google Scholar 

  • So YT, Beckstead JH, Davis RL (1986) Primary central nervous system lymphoma in acquired immune deficiency syndrome: A clinical and pathological study. Ann Neurol 20: 566–572

    Google Scholar 

  • Stern JJ, Hartman BJ, Sharkey P, Rowland V, Squires KE, Murray HW, Graybill JR (1988) Oral fluconazole therapy for patients with acquired immunodeficiency syndrome and cryptococcosis: Experience with 22 patients. Am J Med 85: 477–480

    Article  PubMed  CAS  Google Scholar 

  • Tervo T, Elovaara I, Karli H, Valle SL, Suni J, Lähdevirta J, Iivanainen M (1986) Abnormal ocular motility as early sign of CNS involvement in HIV infection. Lancet 11: 512

    Article  Google Scholar 

  • Vazeux R, Brousse N, Jarry A et al. (1987) AIDS subacute encephalitis. Identification of infected cells. Am J Pathol 126: 403–410

    Google Scholar 

  • Villa A, Foresti V, Confalonieri F (1987) Autonomic HIV infection and neuropathy. Lancet 11: 915

    Article  Google Scholar 

  • Vishnubakat M, Kaplan M, Farber B, Beresford HR (1988) Effect of azidothymidine (AZT) on peripheral neuropathy of HIV-infected patients: A prospective study. Neurology 38 [Suppl 1]: 241

    Google Scholar 

  • Wiley CA, Schrier RD, Nelson JA, Lampert PW, Oldstone MBA (1986) Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sei 83: 7089–7093

    Article  CAS  Google Scholar 

  • Wong R, Carr G, Kaplan L (1988) Incidence of peripheral neuropathy in patients with group IV HIV infection on zidovudine therapy. IVth International Conference on AIDS. Stockholm 1988

    Google Scholar 

  • Yarchoan R, Thomas RV, Grafman J et al. (1988) Longterm administration of 3′-azido-2′,3′-dideoxythmidine of patients with AIDS-related neurological disease. Ann Neurol 23 [Suppl]: 82–87

    Article  Google Scholar 

  • Zuger A, Louie E, Holzman RS, Simberkoff MS, Rahal JJ (1986) Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Ann Int Med 104: 234–240

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Karl M. Einhäupl
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eva Schielke
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Arbeitsgruppe AIDS, Städt. Krankenhaus Schwabing, Kölner Platz 1, 8000, München 40, Germany

    Hans Jäger

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag, Berlin, Heidelberg New York

About this paper

Cite this paper

Einhäupl, K.M., Schielke, E. (1989). Neurologische Manifestationen. In: Jäger, H. (eds) Frauen und AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74792-2_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74792-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51205-9

  • Online ISBN: 978-3-642-74792-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation