Kinetics of Dye/β-Cyclodextrin Interactions

  • V. C. Reinsborough
  • Y. E. MacPherson
  • R. Palepu
  • Josef F. Holzwarth
Conference paper


The rate of association of β-cyclodextrin (β-CD) with each of three similar azo dyes, methyl orange (MO), methyl red (MR) and pyridine-2-p-dimethylaniline (PADA) was determined by the continuous flow method of integrating observation (CFMIO) at pH 8.4. For all three systems, the rate constants were similar and decreased with increasing dye concentration from 107dm3mol-1 S-1 in l mmol dm-3 of β-CD solution to k = 104 dm3mol-1 S-1 in 7 mmol dm-3 β-CD solution. Discrepancies with joule-heating temperature jump results in the literature disappeared when the rate constants were re-determined in 0.5 mol dm-3 NaCl. The chloride ion was identified as the weakly binding species to β-CD that affected the temperature-jump results. Binding constants were obtained conductometrically for the β-CD/M0 and β-C /MR complex species and for β-CD/PADA by a competitive stopped-flow method. The principal inclusion complex with MO is 1:1 but with MR a considerable quantity of the 2:1 β-CD/MR complex is also formed.


Inclusion Complex Methyl Orange Binding Constant Order Rate Constant Diffusion Control Limit 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • V. C. Reinsborough
    • 1
  • Y. E. MacPherson
    • 2
  • R. Palepu
    • 2
  • Josef F. Holzwarth
    • 3
  1. 1.Department of ChemistryMount Allison UniversitySackville, New BrunswickCanada
  2. 2.Department of ChemistryUniversity College of Cape BretonSydney, Nova ScotiaCanada
  3. 3.Fritz-Haber-InstitutMax-Planck-GesellschaftBerlin 33West Germany

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