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Blutung, Schock und Sepsis

  • H. Graeff
  • R. Deckardt
Conference paper

Zusammenfassung

Blutung und Sepsis können durch Fehlverteilung des Herz-zeitvolumens mit Reduktion der Gewebeperfusion zu einem Multiorganversagen führen. Die pathophysiologischen Veränderungen der Blutung können dabei durch rechtzeitiges Erkennen der Blutungsursache (Blutung infolge Gefäßverletzung, Gerinnungsstörung) und deren Beseitigung meist behoben werden. Die pathophysiologischen Veränderungen der Sepsis werden durch Toxine hervorgerufen, deren mediatorvermittelte, kaskadenartige Wirkung nahezu alle Organsysteme des Körpers beeinflußt. Das Wissen um prädisponierende Faktoren für die Entwicklung dieses Krankheitsbildes, rechtzeitiges Erkennen der Zeichen und Symptome, Verständnis der pathobiochemischen und pathophysiologischen Veränderungen sind unabdingbar für eine erfolgreiche Therapie des septischen Schocks, deren Schwerpunkt die Herdsanierung ist.

Summary

Hemorrhage and sepsis may lead to multiple organ system failure caused by a redistribution of cardiac output and a reduction of tissue perfusion. The pathophysiologic changes caused by hemorrhage are frequently prevented by rapid diagnosis of the cause of the bleeding (e.g., vessel injury or coagulation disorder) and its therapy. The pathophysiologic changes in sepsis are mediated by toxins which affect almost every organ system. Knowledge of the predisposing factors, rapid recognition of signs and symptoms, and understanding of the underlying pathobiochemical and pathophysiologic changes are mandatory in the successful therapy of septic shock. The main therapeutic principle remains removal of the focus.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. Graeff
    • 1
  • R. Deckardt
    • 1
  1. 1.Frauenklinik und PoliklinikTechnischen Universität rechts der IsarMünchenDeutschland

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