Advertisement

Adrenozeptoren und Schwangerschaftshypertonie

  • M. Middeke
Conference paper

Zusammenfassung

Der Schwangerschaftshochdruck ist durch eine gesteigerte vaskuläre Reaktivität gekennzeichnet. In Parallelität zur essentiellen Hypertonie könnte man annehmen, daß hier ebenfalls ein Anstieg der beta-2-Adrenozeptor Dichte eine Rolle spielen könnte. Der Lymphozyt ist ein gutes Modell, um dieses System zu untersuchen. Dadurch würde sich eine Lücke in der Pathogenese der Schwangerschaftshypertonie schließen lassen.

Summary

During the last 10 years, radioligand binding studies have greatly advanced our knowledge about adrenoceptors in circulating lymphocytes. In essential hypertension the activity of the sympathetic system seems to be altered. Stimulation of the sympathetic system leads to rapid increase of lymphocyte beta-2-adrenoceptor density. In contrast, gestational hypertension is characterized by a decrease in cardiac output and enhanced arteriolar and venolar resistance. Peripheral resistance is modulated by alpha- and beta adrenoceptors and further studies are needed to characterize and quantify adrenoceptor density in gestational hypertension.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Redman CWG, Beilin LJ, Bonnar J, Qunsted MK (1976) Variability of blood pressure in normal and abnormal pregnancy. In: Lindheimer MD, Katz AI, Zuspan FD (eds) Hypertension in pregnancy. Wiley, New York, pp 53–60Google Scholar
  2. 2.
    Dame WR, Bachour G, Böttcher HD, Beller FK (1977) Direkte kontinuierliche Blutdruckmessung bei normalen und präeklamptischen Schwangeren. Geburtsh Frauenheilk 37: 708PubMedGoogle Scholar
  3. 3.
    Middeke M, Beck B, Mika E, Holzgreve H (1988) Zirkadianes Blutdruckprofil bei sekundärer Hypertonie. Wissenschaftl. Tagung Deutscher Hochdruckliga, Berlin November 1988: Clin, and Exp. Hypertension (1989)Google Scholar
  4. 4.
    Goldstein DS (1981) Plasma norepinephrine in essential hypertension A study of the studies. Hypertension 3: 48PubMedGoogle Scholar
  5. 5.
    Goldenberg Z, Pines KL, Baldwin EDF, Greene DG, Roh CE (1948) The hemodynamic response of man to norepinephrine and epinephrine and its relation to the problem of hypertension. Am J Med 5: 792PubMedCrossRefGoogle Scholar
  6. 6.
    Middeke M, Remien J, Block LH, Kirzinger S, Landrock A, Holzgreve H (1983) Beta2-Adrenoceptor density on membranes and on intact mono nuclear cells in essential hypertension. Res Exp Med 183: 227–232CrossRefGoogle Scholar
  7. 7.
    Brodde OE, Prywarra A, Anlauf M, Daul A, Bock KD (1983) Increased number of ß2-adrenoceptors in circulating lymphocytes of patients with essential hypertension. J Hypertens 1 (suppl 2): 26–66Google Scholar
  8. 8.
    Middeke M, Remien J, Holzgreve H (1984) The influence of sex, age, blood pressure and physical stress on ß2-adrenoceptor density of mononuclear cells. J Hypertens 2: 261–264PubMedGoogle Scholar
  9. 9.
    Jones CR, Elliot HL, Deighton N, Howie CA, Reid JL (1985) Alpha-adrenoceptor number and function in platelets from treated and untreated patients with essential hypertension and age and sex matched controls. J Hypertens 3 (suppl 3): 153Google Scholar
  10. 10.
    Brodde OE, Daul AE, O’Hara N, Khalifa AM (1985) Properties of alpha- and beta- adrenoceptors in circulating blood cells of patients with essential hypertension. J Cardiovasc Pharmacol 7 (suppl 6): 162CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • M. Middeke
    • 1
  1. 1.Medizinische PoliklinikUniversität MünchenDeutschland

Personalised recommendations