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Mammary-Derived Growth Inhibitor

  • Chapter
Peptide Growth Factors and Their Receptors II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 2))

Abstract

Today search for growth-regulating polypeptides is guided by a model which postulates control of cell proliferation by both positive and negative signals. Although Bullough and Lawrence (1960) and Iversen (1960) developed the chalone theory in 1960, the existence of growth inhibitors was not demonstrated until recently. This theory postulates a simple feedback mechanism: tissues produce specific compounds (chalones), which inhibit proliferation in the producing tissues. The more tissue is present, the more chalone will be produced and the less growth will proceed. Purification of growth inhibitors has progressed rather slowly. Several attempts have been undertaken to purify a chalone from the epidermis, granulocytes, lymphocytes, or liver (for reviews, see Iversen 1981; Langen 1985; Chap. 28).

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Authors
  1. R. Grosse
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  2. P. Langen
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Editor information

Editors and Affiliations

  1. Laboratory of Chemoprevention, National Cancer Institute, 20892, Bethesda, MD, USA

    Michael B. Sporn M. D.  & Anita B. Roberts Ph. D.  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Grosse, R., Langen, P. (1990). Mammary-Derived Growth Inhibitor. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors II. Handbook of Experimental Pharmacology, vol 95 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74781-6_9

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  • DOI: https://doi.org/10.1007/978-3-642-74781-6_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74783-0

  • Online ISBN: 978-3-642-74781-6

  • eBook Packages: Springer Book Archive

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