Expression of Growth Factors and Their Receptors in Development

  • D. C. Lee
  • K. M. Han
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 95 / 2)


The discovery and characterization of growth factors and their receptors has led to considerable interest in the roles these molecules play in early development. The relatively recent cloning of cDNAs for many of these molecules has meant that efforts to understand the developmental functions of growth factors need no longer be limited to in vitro studies. Information gained from these analyses can now be weighed in the light of detailed knowledge of their developmental expression. Thus, our aim in writing this review has been to integrate data gleaned from studies of the effects of various growth factors on fetal tissues and cells in vitro with those aimed to analyzing their expression in vivo. The inevitable limitations of space have prompted us to concentrate on the latter.


Epidermal Growth Factor Nerve Growth Factor Palatal Shelf Nerve Growth Factor Expression Epidermal Growth Factor Family 
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© Springer-Verlag Berlin Heidelberg 1990

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  • D. C. Lee
  • K. M. Han

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