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Pentapeptide Growth Inhibitors

  • Chapter
Peptide Growth Factors and Their Receptors II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 2))

Abstract

The hemoregulatory peptide and the epidermal pentapeptide are small oligopeptides (molecular weight around 500–600) involved in the regulation of proliferation in their respective tissues in vitro and in vivo. The identification of these peptides was achieved after a 20–year-long search for specific endogenous feedback inhibitors of proliferation initiated by P. Weiss and Kavanau (1957), Bullough and Laurence (1960), and Iversen (1960). Both peptides function in a similar way in their respective tissues. They probably originate from differentiated (mature) cells, i. e. polymorphonuclear neutrophil (PMN) granulocytes or mature keratinocytes, respectively, and they reduce the proliferative activity in their progenitor cells (stem cells, myeloid progenitors, or epidermal basal cells). They are similar (Fig. 1) in chemical structure, suggesting a larger family of regulatory peptides of which the hemoregulatory peptide and the epidermal pentapeptide are the first known members.

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Authors
  1. W. R. Paukovits
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  2. K. Elgjo
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  3. O. D. Laerum
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Editors and Affiliations

  1. Laboratory of Chemoprevention, National Cancer Institute, 20892, Bethesda, MD, USA

    Michael B. Sporn M. D.  & Anita B. Roberts Ph. D.  & 

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Paukovits, W.R., Elgjo, K., Laerum, O.D. (1990). Pentapeptide Growth Inhibitors. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors II. Handbook of Experimental Pharmacology, vol 95 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74781-6_10

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  • DOI: https://doi.org/10.1007/978-3-642-74781-6_10

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