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Genetic Susceptibility to Chemical Carcinogens

  • Chapter
Chemical Carcinogenesis and Mutagenesis II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 94 / 2))

Abstract

It is very well documented that environmental carcinogens including chemicals, radiation and viruses play a major, perhaps even a dominating, role in the aetiology of the whole range of neoplastic diseases. It is equally clear that factors intrinsic to the patient or animal host also influence both the occurrence of cancer and the biological behaviour of the neoplasm. The principal intrinsic variables are age, hormone balance, immune response and genetic constitution. Moreover, these extrinsic and intrinsic factors interact with each other, sometimes in a quite remarkable way.

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  1. D. G. Harnden
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  1. Chester Beatty Laboratories, The Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, SW3 6JB, London, Great Britain

    Colin S. Cooper Ph. D.  & Philip L. Grover D. Sc.  & 

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Harnden, D.G. (1990). Genetic Susceptibility to Chemical Carcinogens. In: Cooper, C.S., Grover, P.L. (eds) Chemical Carcinogenesis and Mutagenesis II. Handbook of Experimental Pharmacology, vol 94 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74778-6_8

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