Genetic Susceptibility to Chemical Carcinogens

  • D. G. Harnden
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 94 / 2)


It is very well documented that environmental carcinogens including chemicals, radiation and viruses play a major, perhaps even a dominating, role in the aetiology of the whole range of neoplastic diseases. It is equally clear that factors intrinsic to the patient or animal host also influence both the occurrence of cancer and the biological behaviour of the neoplasm. The principal intrinsic variables are age, hormone balance, immune response and genetic constitution. Moreover, these extrinsic and intrinsic factors interact with each other, sometimes in a quite remarkable way.


Genetic Susceptibility Poor Metabolisers Chemical Carcinogen Xeroderma Pigmentosum Ataxia Telangiectasia 
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  • D. G. Harnden

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