Inhibition of Chemical Carcinogenesis

  • J. DiGiovanni
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 94 / 2)


Many compounds are known to modify (inhibit or enhance) the development of tumors in response to various carcinogenic agents in experimental animals (reviewed in Slaga 1980). Epidemiological studies have suggested that specific, pharmcologically active agents present in the diet may reduce the relative risk of exposure to carcinogens. For example, an inverse correlation between dietary selenium levels and human cancer mortality has been noted (Shamberger and Willis 1971; Shamberger et al. 1976). Also, Graham et al. (1978) have reported that there is an inverse correlation between the intake of cabbage and human colon cancer. An important consideration in cancer research today is that exposure to pharmacologically active “modifying” chemicals may play an important role in reducing or, in some instances, increasing the relative risks resulting from exposure to carcinogenic chemicals. This chapter focuses on inhibitors of chemical carcinogenesis in experimental animals. Interest in chemical inhibitors of carcinogenesis is twofold: (i) they provide valuable tools for studying the biochemical and molecular mechanism(s) of carcinogenesis; and (ii) understanding their chemical nature, mechanism(s), and specificity may lead to a rational approach for the chemoprevention of chemically induced tumors in humans.


Polycyclic Aromatic Hydrocarbon Mouse Skin Skin Tumor Chemical Carcinogenesis Fluocinolone Acetonide 
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© Springer-Verlag Berlin Heidelberg 1990

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  • J. DiGiovanni

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