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Chemical Carcinogenesis and Mutagenesis I pp 267–325Cite as

Metabolic Activation and DNA Adducts of Aromatic Amines and Nitroaromatic Hydrocarbons

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 94 / 1))

Abstract

The commercial production of aromatic amines and nitroaromatic hydrocarbons began in the middle 1800s following the synthesis of aniline and the aniline-based dyes, rosaniline and mauve. Thirty years later, Rehn (1895) noted an increased incidence of urinary bladder cancer in German dyestuff workers, which Leichtenstern (1898) suggested could be due to their exposure to naphthylamines. This initial report was rapidly followed by additional epidemiological studies until it became incontrovertible that exposure to 2-naphthylamine, benzidine, and 4-aminobiphenyl could lead to the induction of bladder cancer in humans (reviewed in Parkes and Evans 1984).

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Authors
  1. F. A. Beland
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  2. F. F. Kadlubar
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Editors and Affiliations

  1. Chester Beatty Laboratories, The Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, SW3 6JB, London, Great Britain

    Colin S. Cooper Ph.D.  & Philip L. Grover D.Sc.  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Beland, F.A., Kadlubar, F.F. (1990). Metabolic Activation and DNA Adducts of Aromatic Amines and Nitroaromatic Hydrocarbons. In: Cooper, C.S., Grover, P.L. (eds) Chemical Carcinogenesis and Mutagenesis I. Handbook of Experimental Pharmacology, vol 94 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74775-5_8

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  • DOI: https://doi.org/10.1007/978-3-642-74775-5_8

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