Metabolic Activation and DNA Adducts of Aromatic Amines and Nitroaromatic Hydrocarbons

  • F. A. Beland
  • F. F. Kadlubar
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 94 / 1)


The commercial production of aromatic amines and nitroaromatic hydrocarbons began in the middle 1800s following the synthesis of aniline and the aniline-based dyes, rosaniline and mauve. Thirty years later, Rehn (1895) noted an increased incidence of urinary bladder cancer in German dyestuff workers, which Leichtenstern (1898) suggested could be due to their exposure to naphthylamines. This initial report was rapidly followed by additional epidemiological studies until it became incontrovertible that exposure to 2-naphthylamine, benzidine, and 4-aminobiphenyl could lead to the induction of bladder cancer in humans (reviewed in Parkes and Evans 1984).


Chinese Hamster Ovary Cell Aromatic Amine Mutagenic Response Heterocyclic Aromatic Amine Major Adduct 
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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • F. A. Beland
  • F. F. Kadlubar

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