In Vivo Testing for Carcinogenicity

  • W. Lijinsky
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 94 / 1)


Until this century, cancer was a rare disease, and there was no great interest in its nature or origin. Physicians were properly most concerned with the infectious diseases which carried off large proportions of the population, particularly the very young. Concern with those infectious diseases which kill a large portion of the population before middle age is still overwhelming in most of the world, especially in Asia and Latin America. With a few exceptions, cancer is a disease of older people and, therefore, a major problem only in the industrialized countries of Europe and North America. As survival rates improve in any country, it is likely that the incidence of cancer will increase and the urge to prevent this disease will become stronger, since cure is usually difficult and frequently impossible.


Maximum Tolerate Dose Nasal Mucosa Syrian Hamster Styrene Oxide Carcinogenic Activity 
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© Springer-Verlag Berlin Heidelberg 1990

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  • W. Lijinsky

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