Advances in Tobacco Carcinogenesis

  • D. Hoffmann
  • S. S. Hecht
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 94 / 1)

Abstract

In their first reports on smoking and disease both the Royal College Of Physicians Of London (1962) and the US Surgeon General Of The Public Health Service (1964) concluded that cigarette smoking is causally related to lung cancer in humans and is associated with cancer of the oral cavity, larynx and urinary bladder. These conclusions were based on epidemiological data and were supported by laboratory studies. Today, 25 years later and after extensive research, epidemiological reports from more than 20 countries have led the US Surgeon General (1986 a) and the International Agency For Research On Cancer (1986) to the conclusion that smoking of cigarettes is causally related to cancer of the respiratory tract, the upper digestive tract, pancreas, renal pelvis and bladder and that cigarette smokers also face an increased risk for cancer of the cervix. Cigar and pipe smoking are also causally related to cancer of the respiratory tract, oral cavity and esophagus, although, in the case of lung cancer, not to the same extent as cigarette smoking (US Surgeon General 1986 a; IARC 1986). In addition to active smoking, involuntary smoking, i. e., the exposure to environmental tobacco smoke, has been incriminated as a risk factor for cancer of the lung in nonsmokers (IARC 1986; US National Research Council 1986; US Surgeon General 1986 a). Furthermore, chewing of tobacco and especially the oral use of snuff were found to be associated with cancer of the oral cavity (IARC 1985 a; US Surgeon General 1986 b) and possibly with cancer of the nasal cavity, kidney and bladder (Brinton et al. 1984; US Surgeon General 1986 a; Kabat et al. 1986; Goodman et al. 1986).

Keywords

Alkaloid Furan Urethane Acridine Acrylonitrile 

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References

  1. Adams JD, O’Mara-Adams KJ, Hoffmann D (1987) Toxic and carcinogenic agents in undiluted mainstream smoke and sidestream smoke of different types of cigarettes. Carcinogenesis 8: 729–731PubMedGoogle Scholar
  2. Alexander AJ, Goggin PL, Cooke MA (1983) A Fourier-transform infrared spectrometric study of the pyrosynthesis of nickel tetracarbonyl and iron pentacarbonyl by combustion of tobacco. Anal Chim Acta 151: 1–12.Google Scholar
  3. Arjungi KN (1976) Areca nut: a review. Arzneimittel Forsch 26: 951–956.Google Scholar
  4. Armitage AK, Turner DM (1970) Absorption of nicotine in cigarette and cigar smoke through the oral mucosa. Nature 226: 1231–1232.PubMedGoogle Scholar
  5. Armstrong B, Doll R (1975) Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 15: 617–631.PubMedGoogle Scholar
  6. Beems RB, Van Beek L (1984) Modifying effect of dietary fat on benzo(a)pyrene-induced respiratory tract tumors in hamsters. Carcinogenesis 5: 413–417.PubMedGoogle Scholar
  7. Belinsky SA, White CM, Boucheron GA, Richardson FC, Swenberg JA, Anderson M (1986) Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(7V-methyl-IV- nitrosamino)-l-(3-pyridyl)-l-butanone. Cancer Res 46: 1280–1284.PubMedGoogle Scholar
  8. Belinsky SA, White CM, Devereux TR, Swenberg JA, Anderson MW (1987) Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(IV-methyl-IV-nitrosamino)-l -(3-pyridyl)-l -butanone. Cancer Res 47: 1143–1148.PubMedGoogle Scholar
  9. Bernfeld P, Homburger F, Russfield AB (1974) Strain differences in the response of inbred Syrian golden hamsters to cigarette smoke inhalation. JNCI 53: 1141–1151.Google Scholar
  10. Binder H, Lindner W (1972) Bestimmung von Aethylenoxyd im Rauch garantiert unbegaster Zigaretten. Fachliche Mitt Osterr Tabakregie 13: 215–220.Google Scholar
  11. Birt DF, Pour PM (1983) Increased tumorigenesis induced by IV-nitroso-fe-(2-oxopropyl)amine in Syrian golden hamsters fed high-fat diets. JNCI 70: 1135–1139.Google Scholar
  12. Borish ET, Cosgrove JP, Church DF, Deutsch WA, Pryor WA (1985) Cigarette tar causes single-strand breaks in DNA. Biochem Biophys Res Commun 133: 780–786.PubMedGoogle Scholar
  13. Brinton LA, Blot WJ, Becker JA, Winn DM, Browder JP, Farmer JC, Fraumeni JF (1984) A case control study of cancers of the nasal cavity and paranasal sinuses. Am J Epidemiol 119: 896–906.PubMedGoogle Scholar
  14. Brunnemann KD, Hoffmann D (1974) The pH of tobacco smoke. Food Cosmet Toxicol 12: 115–124.PubMedGoogle Scholar
  15. Brunnemann KD, Hoffmann D, Wynder EL, Gori GB (1976) Determination of tar, nicotine, and carbon monoxide in cigarette smoke. A comparison of international smoking conditions. Department of Health, Education, and Welfare (DHEW) publ no (NIH) 76 - 1221: 441–449.Google Scholar
  16. Brunnemann KD, Prokopczyk B, Hoffmann D, Nair JH, Ohshima H, Bartsch H (1986) Laboratory studies on oral cancer and smokeless tobacco. Banbury Rep 23: 197–213.Google Scholar
  17. Brunnemann KD, Hornby AP, Stich HF (1987) Tobacco-specific nitrosamines in the saliva of Inuit snuff dippers in the Northwest Territories of Canada. Cancer Lett 37: 7–16.PubMedGoogle Scholar
  18. Bryant MS, Skipper PL, Tannenbaum SR, Maclure M (1987) Hemoglobin adducts of 4-aminobiphenyl in smokers and nonsmokers. Cancer Res 47: 602–608.PubMedGoogle Scholar
  19. Bryant MS, Vineis P, Skipper PL, Tannenbaum SR (1988) Haemoglobin adducts of aromatic amines in people exposed to cigarette smoke. I ARC Sci Publ 89: 133–136.Google Scholar
  20. Carmella SG, Hecht SS (1987) Formation of hemoglobin adducts upon treatment of F344 rats with the tobacco-specific nitrosamines 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone and IV-nitrosonornicotine. Cancer Res 47: 2626–2630.PubMedGoogle Scholar
  21. Carmella SG, Hecht SS, Tso TC, Hoffmann D (1984) Roles of tobacco cellulose, sugars, and chlorogenic acid as precursors to catechol in cigarette smoke. J Agric Food Chem 32: 267–273.Google Scholar
  22. Castonguay A, Foiles PG, Trushin N, Hecht SS (1985) A study of DNA methylation by tobacco-specific IV-nitrosamines. Environ Health Perspect 62: 197–202.PubMedGoogle Scholar
  23. Centers for Disease Control, Atlanta, Georgia (1987) Smoking attributable mortality and years of potential life lost-United States, 1984. MMWR 36: 693–697.Google Scholar
  24. Chung FL,.Tanaka T, Hecht SS (1986) Induction of liver tumors in F344 rats by crotonaldehyde. Cancer Res 46: 1285–1289.Google Scholar
  25. Church DF, Pryor WA (1985) Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 64: 111–126.PubMedGoogle Scholar
  26. Cohen LA (1987) Diet and cancer. Sci Am 257: 42–48PubMedGoogle Scholar
  27. Connolly GN, Winn DM, Hecht SS, Henningfield JE, Walker B Jr, Hoffmann D (1986) The reemergence of smokeless tobacco. N Engl J Med 314: 1020–1027.PubMedGoogle Scholar
  28. Cosgrove JP, Borish ET, Church DF, Deutsch WA, Pryor WA (1985) The metal-mediated formation of hydroxy-radical by aqueous extracts of cigarette tar. Biochem Biophys Res Commun 132: 390–396.PubMedGoogle Scholar
  29. Davis BR, Whitehead JK, Gill ME, Lee PN, Butterworth AD, Roe FJC (1975) Response of rat lung to tobacco smoke condensate or fractions derived from it administered repeatedly by intratracheal instillation. Br J Cancer 31: 453–461.PubMedGoogle Scholar
  30. Deutsch-Wenzel RP, Brune H, Grimmer G, Dettbarn G, Misfeld J (1983) Experimental studies in rat lungs on the carcinogenicity and dose-response relationships of eight frequently occurring environmental polycyclic aromatic hydrocarbons. JNCI71: 539–544.Google Scholar
  31. Doll R (1971) Cancers related to smoking. Proc 2nd world conf, Smoking and health. Pitman Med, London, pp 10–23.Google Scholar
  32. Doll R, Peto R (1981) The causes of cancer. Quantitative estimates of available risks of cancer in the United States today. JNCI 66: 1191–1308.Google Scholar
  33. Dong M, Schmeltz I, Jacobs E, Hoffmann D (1978) Aza-arenes in tobacco smoke. J Anal Chem 2: 21–25.Google Scholar
  34. Dontenwill WP (1974) Tumorigenic effects of chronic cigarette smoke inhalation on Syrian golden hamsters. In: Karbe E, Park JF (eds) Experimental lung cancer - carcinogenesis and bioassays. Springer, Berlin Heidelberg New York, pp 331–359.Google Scholar
  35. Dube MF, Green CR (1982) Methods of collection of smoke for analytical purposes. Recent Adv Tobacco Sci 8: 42–102.Google Scholar
  36. El-Bayoumy K, Donahue J, Hecht SS, Hoffmann D (1986) Identification and quantitation of aniline and toluidines in urine of smokers and nonsmokers. Cancer Res 46: 6064–6067.PubMedGoogle Scholar
  37. Enzell CR, Wahlberg I, Aasen AJ (1977) Isoprenoids and alkaloids of tobacco. Progr Chem Org Nat Products 34: 1–79.Google Scholar
  38. Everson RB, Randerath E, Santella SA, Cefalo RC, Avitts TA, Randerath K (1986) Detection of smoking-related covalent DNA adducts in human placenta. Science 231: 54–57.PubMedGoogle Scholar
  39. Foiles PG, Miglietta LA, Akerkar SA, Everson RB, Hecht SS (1988) Detection of O6- methyldeoxyguanosine in human placental DNA. Cancer Res 48: 4184–4188.PubMedGoogle Scholar
  40. Goodman MT, Morgenstern H, Wynder EL (1986) A case-control study of factors affecting the development of renal cell cancer. Am J Epidemiol 124: 926–941.PubMedGoogle Scholar
  41. Green CR (1977) Some relationship between tobacco leaf and smoke composition. Proc Am Chem Soc Symp, Recent advances in the chemical composition of tobacco and tobacco smoke, New Orleans, pp 426–470.Google Scholar
  42. Green LC, Skipper PL, Juresky RJ, Bryant MS, Tannenbaum SR (1984) In vivo dosimetry of 4-aminobiphenyl in rats via a cysteine adduct in hemoglobin. Cancer Res 44: 4254–4259.PubMedGoogle Scholar
  43. Greenberg RA, Haley NJ, Etzel RA, Loda FA (1984) Measuring the exposure of infants to tobacco smoke: nicotine and cotinine in saliva and urine. N Engl J Med 310: 1075–1078.PubMedGoogle Scholar
  44. Guerin MR (1987) Formation and physicochemical nature of sidestream smoke. IARC Sci Publ 81: 11–23PubMedGoogle Scholar
  45. Gupta PC, Pindborg J J, Mehta FS (1982) Comparison of carcinogenicity of betel-quid with and without tobacco. An epidemiological review. Ecol Dis 1: 213–219.Google Scholar
  46. Haley NJ, Sepkovic DW, Hoffmann D, Wynder EL (1985) Cigarette smoking as a risk factor for cardiovascular disease Part VI. Compensation with nicotine available as a single variable. Clin Pharmacol Ther 38: 164–170.Google Scholar
  47. Harley NH, Cohen BS, Tso TC (1980) Polonium-210. A questionable risk factor in smoking-related carcinogenesis. Banbury Rep 3: 93–104.Google Scholar
  48. Harris CC, Vahakangas K, Newman MJ, Trivers GE, Shamsuddin A, Sinopoli N, Mann D, Wright WE (1985) Detection of benzo(a)pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc Natl Acad Sei 82: 6672–6676.Google Scholar
  49. Hayashi Y, Nagao M, Sugimura T, Takayama S, Tomatis L, Wattenberg LW, Wogan GN (eds) (1986) Diet, nutrition and cancer. Japan Sci Soc Press, Tokyo, p 345.Google Scholar
  50. Hayes AW, Coggins CRE, Ayres PH, Burger GT, Mosberg AT (1988) Ninety-day inhalation study in rats comparing smoke from cigarettes with burned or only heated tobacco. Toxicol Abstr 8: 252–254.Google Scholar
  51. Hecht SS, Hoffmann D (1988) Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis 9: 875–884.PubMedGoogle Scholar
  52. Hecht SS, Thorne RL, Maronpot RR, Hoffmann D (1975) Tumor promoting subfractions of the weakly acidic fraction. JNCI 55: 1329–1336.Google Scholar
  53. Hecht SS, Loy M, Maronpot RR, Hoffmann D (1976) A study of chemical carcinogenesis: comparative carcinogenicity of 5-methylchrysene, benzo(a)pyrene, and modified chrysenes. Cancer Lett 1: 147–154.Google Scholar
  54. Hecht SS, Carmella S, Mori H, Hoffmann D (1981) Role of catechol as a major coearcinogen in the weakly acidic fraction of smoke condensate. JNCI 66: 163–169.Google Scholar
  55. Hecht SS, Adams JD, Numoto S, Hoffmann D ( 1983 a) Induction of respiratory tract tumors in Syrian golden hamsters by a single dose of 4-(methylnitrosamino)-l-(3- pyridyl)-l-butanone ( NNK) and the effect of smoke inhalation. Carcinogenesis 4: 1287–1290.Google Scholar
  56. Hecht SS, Castonguay A, Rivenson A, Mu B, Hoffmann D (1983 b) Tobacco-specific nitrosamines: carcinogenicity, metabolism, and possible role in human cancer. J Environ Health Sci CI 1: 1–54.Google Scholar
  57. Hecht SS, Trushin N, Castonguay A, Rivenson A (1986 a) Comparative carcinogenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-l-(3-pyridyl)-l- butanone and JV-nitrosodimethylamine. Cancer Res 46: 498–504.Google Scholar
  58. Hecht SS, Rivenson A, Braley J, DiBello J, Adams JD, Hoffmann D (1986 b) Induction of oral cavity tumors in F344 rats by tobacco-specific nitrosamines and snuff. Cancer Res 46: 4162–4166.Google Scholar
  59. Hecht SS, Melikian AA, Amin S (1986 c) Methylchrysenes as probes for the mechanisms of metabolic activation of carcinogenic methylated polynuclear aromatic hydrocarbons. Acc Chem Res 19: 4162–4166.Google Scholar
  60. Hecht SS, Amin S, Huie K, Melikian AA, Harvey RG (1987) Enhancing effects of a bay region methyl group on tumorigenicity of enantiomeric bay region diol epoxides formed stereoselectively from methylchrysenes in mouse epidermis. Cancer Res 47: 5310–5315.PubMedGoogle Scholar
  61. Hecht SS, Spratt TE, Trushin N (1988) Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4- (methylnitrosamino)-l -(3-pyridyl)-l -butanone and IV’-nitrosonornicotine. Carcinogenesis 9: 161–165.PubMedGoogle Scholar
  62. Herning RI, Jones RT, Bachman J, Mines AH (1981) Puff volume increases when low-nicotine cigarettes are smoked. Br J Med 283: 187–189.Google Scholar
  63. Higginson J, Muir CS (1979) Environmental carcinogenesis: misconceptions and limitations to cancer control. JNCI 63: 1291–1298.Google Scholar
  64. Hirayama T (1966) An epidemiological study of oral and pharyngeal cancer in central and South-East Asia. Bull WHO 34: 41–69.PubMedGoogle Scholar
  65. Hirsch JM, Johannson SL (1983) Effect of long-term application of snuff on oral mucosa. An experimental study in the rat. J Oral Pathol 12: 187–189.Google Scholar
  66. Hoffmann D, Adams JD (1981) Carcinogenic tobacco-specific IV-nitrosamines in snuff and in the saliva of snuff dippers. Cancer Res 41: 4305–4308.PubMedGoogle Scholar
  67. Hoffmann D, Harris CC (eds) (1986) Mechanisms in tobacco carcinogenesis. Banbury Rep 23. Cold Spring Harbor Laboratories, New York Hoffmann D, Hecht SS (1985) Nicotine-derived AT-nitrosamines and tobacco-related cancer: current status and future directions. Cancer Res 45: 935–944.Google Scholar
  68. Hoffmann D, Rathkamp G (1968) Primary and secondary nitroalkanes in cigarette smoke. Beitr Tabakforsch 4: 124–134.Google Scholar
  69. Hoffmann D, Wynder EL (1971) A study of tobacco carcinogenesis. XI. Tumor initiators, tumor accelerators, and tumor promoting activity of condensate fractions. Cancer 27: 848–864.Google Scholar
  70. Hoffmann D, Wynder EL (1986) Chemical constituents and bioactivity of tobacco smoke. IARC Sci Publ 74: 145–165.PubMedGoogle Scholar
  71. Hoffmann D, Schmeltz I, Hecht SS, Wynder EL (1978) Polynuclear aromatic hydrocarbons in tobacco carcinogenesis. In: Gelboin G, Ts’o PO (eds) Polynuclear hydrocarbons and cancer, vol 1. Chemistry, molecular biology and environment. Academic, New York, pp 85–117.Google Scholar
  72. Hoffmann D, Rivenson A, Hecht SS, Hilfrich J, Kobayashi N, Wynder EL (1979) Model studies in tobacco carcinogenesis with the Syrian golden hamster. Progr Exp Tumor Res 24: 370–390.PubMedGoogle Scholar
  73. Hoffmann D, Tso TC, Gori GB (1980) The less harmful cigarette. Prev Med 9: 287–296.PubMedGoogle Scholar
  74. Hoffmann D, Brunnemann KD, Adams JD, Hecht SS (1984) Formation and analysis of TV-nitrosamines in tobacco products and their endogenous formation in consumers. IARC Sci Publ 57: 743–762.PubMedGoogle Scholar
  75. Hoffmann D, Adams JD, Lisk D, Fisenne I, Brunnemann KD (1987) Toxic and carcinogenic agents in dry and moist snuff. JNCI 79: 1281–1286.Google Scholar
  76. Hoffmann D, Brunnemann KD, Venitt S (1988) Carcinogenic nitrosamines in oral snuff. Lancet 1: 1232PubMedGoogle Scholar
  77. Ingebrethsen BJ (1986) Aerosol studies of cigarette smoke. Recent Adv Tobacco Sci 12: 54–142Google Scholar
  78. International Agency for Research on Cancer (1972) 4-Aminobiphenyl. IARC Monogr 1:74–79.Google Scholar
  79. International Agency for Research on Cancer (1973) Nickel and inorganic nickel compounds. IARC Monogr 3: 126–149.Google Scholar
  80. International Agency for Research on Cancer (1974 a) 2-Naphthylamine. IARC Monogr 4:97–111.Google Scholar
  81. International Agency for Research on Cancer (1974 b) Benzene. IARC Monogr 7:203–221.Google Scholar
  82. International Agency for Research on Cancer (1974 c) Hydrazine. IARC Monogr 4:127–136Google Scholar
  83. International Agency for Research on Cancer (1974d) Urethane. IARC Monogr 7: 111–140Google Scholar
  84. International Agency for Research on Cancer (1976) Coumarin. IARC Monogr 10: 113–119Google Scholar
  85. International Agency for Research on Cancer (1979 a) Ethylene and polyethylene. IARC Monogr 19:157–186.Google Scholar
  86. International Agency for Research on Cancer (1979 b) Acrylonitrile. I ARC Monogr 19:73–113.Google Scholar
  87. International Agency for Research on Cancer (1979 c) Vinyl chloride. I ARC Monogr 19:377–438.Google Scholar
  88. International Agency for Research on Cancer (1980 a) Arsenic and arsenic compounds. IARC Monogr 23:39–141.Google Scholar
  89. International Agency for Research on Cancer (1980 b) Chromium and chromium compounds. IARC Monogr 23:205–323.Google Scholar
  90. International Agency for Research on Cancer (1980c) Lead and lead compounds. IARC Monogr 23: 325–415.Google Scholar
  91. International Agency for Research on Cancer (1982 a) Formaldehyde (gas). IARC Monogr [Suppl] 4:131–132.Google Scholar
  92. International Agency for Research on Cancer (1982 b) Benzene. IARC Monogr 29:93–148.Google Scholar
  93. International Agency for Research on Cancer (1982 c) 2-Nitropropane. IARC Monogr 29:331–343.Google Scholar
  94. International Agency for Research on Cancer (1985 a) Tobacco habits other than smoking;betel-quid and areca-nut chewing; and some related nitrosamines. IARC Monogr 37.Google Scholar
  95. International Agency for Research on Cancer (1985 b) Ethylene oxide. IARC Monogr 36:189–226Google Scholar
  96. International Agency for Research on Cancer (1986) Tobacco smoking. IARC Monogr 38 Ip C, Birt DF, Rogers AE, Mettlin C (eds) (1986) Dietary fat and cancer. Liss, New York Ivankovic S, Eisenbrand G, Preussmann R (1979) Lung carcinoma induction in BD rats after single intratracheal instillation of an arsenic-containing pesticide mixture formerly used in vineyards. Int J Cancer 24: 766–768.Google Scholar
  97. Jarvis MJ, Russell MAH (1985) Tar and nicotine yield of U.K. cigarettes, 1972–1983:sales-weighted estimates from non-industry sources. Br J Addict 80: 429–434.PubMedGoogle Scholar
  98. Jenkins RW Jr, Goldey C, Williamson TG (1985) Neutron activation analysis in tobacco and tobacco smoke studies: 2R1 cigarette composition smoke transference and butt filtration. Beitr Tabakforsch 13: 59–65.Google Scholar
  99. Johnson WR (1977) The pyrogenesis and physicochemical nature of tobacco smoke.Recent Adv Tobacco Sci 3: 1–27.Google Scholar
  100. Kabat GC, Dieck GS, Wynder EL (1986) Bladder cancer in nonsmokers. Cancer 57: 362–367.PubMedGoogle Scholar
  101. Kao-Shan C-S, Fine RL, Whang-Peng J, Lee EC, Chabner BA (1987) Increased fragile sites and sister chromatid exchanges in bone marrow and peripheral blood of young cigarette smokers. Cancer Res 47: 6278–6282.PubMedGoogle Scholar
  102. Kinlen LJ, Rogot E (1988) Leukemia and smoking habits among United States Veterans. Br Med J 297: 657–659.Google Scholar
  103. Klus H, Kuhn H (1982) Verteilung verschiedener Tabakrauchbestandteile auf Haupt- und Nebenstromrauch. Eine Übersicht. Beitr Tabakforsch 11: 229–265.Google Scholar
  104. Klus H, Begutter H, Ball M, Introp I (1987) Environmental tobacco smoke in real life situations. Proc 4th internat conf indoor air quality and climate, vol 2:137–141 Berlin (West)Google Scholar
  105. Kobayashi N, Hoffmann D, Wynder EL (1974) A study of tobacco carcinogenesis. XII. Epithelial changes in the upper respiratory tracts of Syrian golden hamsters by cigarette smoke. JNCI 53: 1085–1089.Google Scholar
  106. Koop CE (1986) The quest for a smoke-free young America by the year 2000. J School Health 56: 8–9.PubMedGoogle Scholar
  107. Krokan H, Grafstrom RC, Sundqvist K, Esterbauer H, Harris CC (1985) Cytotoxicity, thiol depletion and inhibition of 06-methylguanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts. Carcinogenesis 6: 1755–1759.PubMedGoogle Scholar
  108. LaVoie EJ, Prokopczyk G, Rigotty J, Czech A, Rivenson A, Adams JD ( 1987 a) Tumorigenic activity of the tobacco-specific nitrosamines 4-(methylnitrosamino)-l-(3- pyridyl)-1 -butanone (NNK), 4-(methylnitrosamino)-4-(3-pyridyl)-l-butanol (iso- NNAL) and iV-nitrosonornicotine ( NNN) on topical application to Senear mice. Cancer Lett 37: 277–283.Google Scholar
  109. LaVoie EJ, Shigematsu A, Rivenson A (1987 b) The carcinogenicity of quinoline and ben- zoquinolines in newborn CD-I mice. Gann 78: 139–143.Google Scholar
  110. LaVoie EJ, Tucciarone P, Kagan M, Adams JD, Hoffmann D (1988) Quantitative analyses of steam distillates and aqueous extracts of smokeless tobacco. J Agr Food Chem 31: 154–157.Google Scholar
  111. Lee PN (1987) Lung cancer and passive smoking: association an artifact due to misclas-sification of smoking habits. Tox Lett 35: 157–162.Google Scholar
  112. Leffingwell JC, Young HJ, Bernasek E (1972) Tobacco flavoring for smoking products. RJ Reynolds Tobacco Company, Winston Salem, North Carolina Lewtas J, Williams K, Loefroth G, Hammond K, Laederer B (1987) Environmental tobacco smoke: mutagenic emission rates and their relationship to other emission factors. Proc 4th internat conf on indoor quality and climate, vol 2:8–12 Berlin (West).Google Scholar
  113. Liu YY, Schmeltz I, Hoffmann D (1974) Quantitative analyses of hydrazine in tobacco and cigarette smoke. Anal Chem 46: 885–88900.PubMedGoogle Scholar
  114. Maxwell JC Jr (1981) Smokeless tobacco: the economy stunted growth. Tobacco Reporter 108 (7): 34–35.Google Scholar
  115. Maxwell JC Jr (1986) Smokeless sales drop in US. Tobacco Reporter 113 (8): 36–37.Google Scholar
  116. Melikian AA, Leszczynska JM, Hecht SS, Hoffmann D (1986) Effects of the cocarcinogen catechol on metabolism and DNA formation by benzo(a)pyrene in mouse skin in vivo. Carcinogenesis 7: 9–15.PubMedGoogle Scholar
  117. Nair JH, Ohshima H, Malaveille C, Friesen IK, O’Neill AA (1986 a) Identification, occurrence and mutagenicity in S. typhimurium of two synthetic nitroarenes, musk ambrette and musk xylene, in Indian chewing tobacco and betel quid. Food Chem Toxicol 24: 27–31.Google Scholar
  118. Nair J, Ohshima H, Pignatelli B, Friesen M, Malaveille C, Calmels S, Bartsch H (1986 b) Modifiers of endogenous carcinogen formation: studies on in vivo nitrosation in tobacco users, Banbury Rep 23: 45–61.Google Scholar
  119. Nakayama T, Kodama M, Nagata C (1984) Generation of hydrogen peroxide and superoxide anion radical from cigarette smoke. Gann 75: 95–98.PubMedGoogle Scholar
  120. Nakayama T, Kaneko M, Kodama M (1986) Volatile gas components contribute to cigarette-smoke-induced DNA single strand breaks in cultured human cells. Agr Biol Chem 50: 1319–1320.Google Scholar
  121. National Council on Radiation Protection and Measurement (1987) Ionizing radiation exposure of the population of the United States. NCRP rep no 93, Bethesda, MD National Research Council. Committee on Medical and Biological Effects of Environmental Pollutants ( 1975 ) Nickel. Natl Acad Sci, Washington DC, publ no 75–1475.Google Scholar
  122. Neumann HG (1984) Analysis of hemoglobin as a dose monitor for alkylating and arylating agents. Arch Toxicol 56: 1–6.PubMedGoogle Scholar
  123. Norman V (1977) An overview of the vapor phase semi-volatile and nonvolatile components of cigarette smoke. Recent Adv Tobacco Sci 3: 28–58.Google Scholar
  124. Norman V (1982) Changes in smoke chemistry of modern day cigarettes. Recent Adv Tobacco Sci 8:144–177 Palladino G, Brunnemann KD, Adams JD, Haley NJ, Hoffmann D (1986) Snuff-dipping in college-students: a clinical profile. Military Med 151: 342–346.Google Scholar
  125. Park NH, Sapp JP, Herbosa EG (1986) Oral cancer induced in hamsters with herpes simplex infection and simulated snuff dipping. Oral Surg Oral Med Oral Pathol 62: 164–168.PubMedGoogle Scholar
  126. Perera FP, Poirier MC, Yuspa SH, Nakayama J, Jaretzki A, Curnen MM, Knowles DM, Weinstein IB (1982) A pilot project in molecular cancer epidemiology: determination of benzo(a)pyrene-DNA adducts in animals and human tissues by immunoassays. Carcinogenesis 3: 1405–1410.PubMedGoogle Scholar
  127. Perfetti TA, Gordin HH (1985) Just noticeable difference studies of mentholated cigarette products. Tobacco Sci 29:57-66 Perinelli MA, Carugno N (1978) Determination of trace metals in cigarette smoke by flameless atomic absorption spectrometry. Beitr Tabakforsch 9: 214–217.Google Scholar
  128. Prokopczyk B, Rivenson A, Bertinato P, Brunnemann KD, Hoffmann D (1987) 3-(Methylnitrosamino)propionitrile: occurrence in saliva of betel quid chewers, carcinogenicity, and DNA methylation in F344 rats. Cancer Res 47: 467–471.Google Scholar
  129. Ranadive KJ, Gothoskar SV, Rao AR, Tezabwella BU, Ambaye RY (1976) Experimental studies on betel-nut and tobacco carcinogenicity. Int J Cancer 17: 469–476.PubMedGoogle Scholar
  130. Randerath E, Avitts TA, Reddy MV, Miller RH, Everson RB, Randerath K (1986) Comparative 32P-analysis of cigarette smoke induces DNA damage in human tissues and mouse skin. Cancer Res 46: 5869–5877.PubMedGoogle Scholar
  131. Reddy BS, Cohen LA, McCoy GD, Hill P, Weisburger JH, Wynder EL (1980) Nutrition and its relationship to cancer. Adv Cancer Res 32: 237–345.PubMedGoogle Scholar
  132. Remmer H (1987) Passively inhaled tobacco smoke: a challenge to toxicology and preventive medicine. Arch Toxicol 61: 8 5–104.Google Scholar
  133. Rivenson A, Hoffmann D, Prokopczyk B, Amin S, Hecht SS (1988) Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and areca-derived N- nitrosamines. Cancer Res 48: 6912–6917.PubMedGoogle Scholar
  134. Royal College of Physicians (1962) Smoking and Health. Pitman, London Russell MAH (1987) Estimation of smoke dosage and mortality of nonsmokers from environmental tobacco smoke. Tox Lett 35: 9–18.Google Scholar
  135. Saffiotti U, Montesano R, Sellakumar AR, Cefis F, Kaufman DG (1972) Respiratory tract carcinogenesis induced in hamsters by different dose levels of benzo(a)pyrene and ferric oxide. JNCI 49: 1199–1204.Google Scholar
  136. Saffiotti U, Stinson SF, Keenan KP, McDowell EM (1985) Tumor enhancement factors and mechanisms in the hamster respiratory tract carcinogenesis model. In: Mass MJ et al. (eds) Carcinogenesis, a comprehensive survey, vol 8. Raven, New York, pp 63–92.Google Scholar
  137. Schmeltz I, Hoffmann D (1977) Nitrogen-containing compounds in tobacco and tobacco smoke. Chem Rev 77: 295–311.Google Scholar
  138. Schmeltz I, Chiong KG, Hoffmann D (1978) Formation and determination of ethyl carbamate in tobacco and tobacco smoke. J Anal Toxicol 2: 265–268.Google Scholar
  139. Sepkovic DW, Axelrad CM, Colosimo SG, Haley NJ (1987) Measuring tobacco smoke exposure: clinical applications and passive smoking. 80th annual meeting. An exhibition of the Air Pollution Control Assoc, New York Shinohara Y, Ogiso T, Hananouchi M, Nakanishi K, Yoshimura T, Ito N (1977) Effect of various factors on the induction of liver tumors in animals by quinoline. Gann 68: 785–796.Google Scholar
  140. Stanton MF, Miller E, Wrench C, Blackwell R (1972) Experimental induction of epidermoid carcinoma in the lungs of rats by cigarette smoke condensate. JNCI 49: 867–877.Google Scholar
  141. Takenaka S, Oldiges H, Koenig H, Hochrainer D, Oberdoerster G (1983) Carcinogenicity of cadmium chloride aerosols in W rats. JNCI 70: 367–373.Google Scholar
  142. Thyssen J, Althoff J, Kimmerle G, Mohr U (1981) Inhalation studies with benzo(a)pyrene in Syrian golden hamsters. JNCI 66: 575–577.Google Scholar
  143. Tobacco Journal International (1987) Production of cigarettes for selected countries. Tobacco J Int (1980):377–379 and (1987): 358–360.Google Scholar
  144. Tobacco Journal International (1988) Only consumption of snuff is rising in Sweden. Tobacco J Int (1988): 180 - 182.Google Scholar
  145. Törnqvist M, Osterman-Golkar S, Kautiainen A, Jensen S, Farmer PB, Ehrenberg L (1986) Tissue doses of ethylene oxide in cigarette smokers determined from adduct levels in hemoglobin. Carcinogenesis 7: 1519–1521.PubMedGoogle Scholar
  146. Tso TC (1972) Physiology and biochemistry of tobacco plants. Dowden, Hutchinson and Ross, Stroudsburg, Pennsylvania.Google Scholar
  147. US Dept of Agriculture, Food Safety, and Quality Service (1983) Nitrates, nitrites and ascorbates (as isoascorbates) in bacon. Fed Regist 256: 347–351.Google Scholar
  148. US Food and Drug Administration (1980) Dimethylnitrosamines in malt beverages; availability of guide. Fed Reg 45: 39341–39342.Google Scholar
  149. US National Research Council (1986) Environmental tobacco smoke-measuring exposures and assessing health effects. National Academy Press, Washington DC.Google Scholar
  150. US Surgeon General (1964) Smoking and health. PHS publ no 1103 Washington DC.Google Scholar
  151. US Surgeon General (1981) The health consequences of smoking - the changing cigarette. DHHS (PHS) 81–50156.Washington DC.Google Scholar
  152. US Surgeon General (1982) The health consequences of smoking - cancer. DHHS publ no (OHS) 82–50179. Washington DC US Surgeon General (1986 a) The health consequences of involuntary smoking. DHHS (CDC) 87–8398.Washington DC.Google Scholar
  153. US Surgeon General (1986b) The health consequences of using smokeless tobacco. NIH publ no 86–2874.Washington DC.Google Scholar
  154. Van Duuren BL, Goldschmidt BM (1976) Cocarcinogenic and tumor promoting agents in tobacco carcinogenesis. JNCI 56: 1237–1242.Google Scholar
  155. Wahlberg I, Enzell CR (1987) Tobacco isoprenoids. Natural Product Rep 1987: 237–276.Google Scholar
  156. Wallace L, Pellizari E, Hartwell TD, Perritt R, Ziegenfus R (1987) Exposures to benzene and other volatile compounds from active and passive smoking. Arch Environ Health 42: 272–279.PubMedGoogle Scholar
  157. Willey JC, Grafstrom RC, Moser CE Jr, Oyanne C, Sundqvist K, Harris CC (1987) Biochemical and morphological effects of cigarette smoke condensate and its fractions on normal human bronchial epithelial cells in vitro. Cancer Res 47: 2045–2049.PubMedGoogle Scholar
  158. Winn DM, Blot WJ, Shy CM, Pickle LW, Toledo A, Fraumeni JF Jr (1981) Snuff-dipping and oral cases among women in the Southern United States. N Engl J Med 304: 745–749.PubMedGoogle Scholar
  159. Wittekindt W (1985) Changes in recommended plant protection agents for tobacco. Tobacco J Int 5: 390–394.Google Scholar
  160. Wynder EL, Gpri GB (1977) Contribution of the environment to cancer incidence. An epidemiologic exercise. JNCI 58: 825–832.Google Scholar
  161. Wynder EL, Hoffmann D (1967) Tobacco and tobacco smoke - studies in experimental carcinogenesis. Academic, New York Wynder EL, Hebert JR, Kabat GC (1987) Association of dietary fat and lung cancer. JNCI 79: 631–637.Google Scholar
  162. Yamashita M, Wakabashi K, Nagao M, Sato S, Yamaizumi Z, Takahashi M, Kinea N, Tomita I, Sugimura T (1986) Detection of 2-amino-3-methylimidazo-[4,5-quinoline in cigarette smoke condensate. Gann 77: 419–422.PubMedGoogle Scholar
  163. Zaridze DG, Blettner M, Trapeznikov NN, Kuvshinov JP, Matiakin EG, Poljakov DP, Poddubni BK, Parshikova SM, Rottenberg VI, Chamrakulov FS, Chodjaeva MC, Stich HF, Rosin MP, Thurnham DI, Hoffmann D, Brunnemann KD (1985) Survey of a population with a high incidence of oral and oesophageal cancer. Int J Cancer 36: 153–158PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • D. Hoffmann
  • S. S. Hecht

There are no affiliations available

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