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Die Pneumocystis carinii Pneumonie pp 74–84Cite as

Pharmakologie von Pentamidin

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Zusammenfassung

Pentamidin ist eine aromatische Diamidinoverbindung, die in den 30er Jahren erstmalig innerhalb einer Reihe von Diamidinoverbindungen synthetisiert (Stilba-midin, Propamidin, Pentamidin) und in den 40er Jahren erfolgreich in der Behandlung der afrikanischen Schlafkrankheit (Trypanosoma rhodiense und gambiense) sowie der Leishmaniose eingesetzt wurde (Schoenbach u. Greenspan 1948). Das antiparasitäre pharmakologische Spektrum der Substanz wurde in den 60er Jahren um die nach neueren Untersuchungen möglicherweise zu den Pilzen zu zählende Pneumocystis carinii erweitert, die bei ätiologisch völlig unterschiedlich immunsupprimierten Patienten eine diffuse interstitielle Pneumonie hervorgerufen hatten (Ivady et al. 1963). Trotz bekannter klinischer Toxizität hat diese antiprotozoale Eigenschaft dem Pentamidin seit Bekanntwerden der Aids-Krank-heit einen bedeutenden Stellenwert in der Therapie der Pneumocystis carinii Pneumonie eingeräumt. Im folgenden soll daher versucht werden, die Pharmakologie dieser Substanz vor dem Hintergrund der neueren Erkenntnisse über eine Inhalationstherapie im Vergleich mit der i.v.-Applikation aufzuzeigen. Hierbei wird ausschließlich das Isethionatsalz von Pentamidin Berücksichtigung finden — eine zweite pharmazeutische Zubereitung, das Methansulfonat von Pentamidin (Lomidine) scheint toxischer zu sein und ist inzwischen aus dem Handel genommen worden.

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Authors
  1. H.-F. Vöhringer
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  2. K. Arasteh
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  3. M. Hornscheidt
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  4. M. L’age
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Editor information

Editors and Affiliations

  1. Bernhard-Nocht-Institut für Tropenmedizin, Bernhard-Nocht-Straß 74, D-2000, Hamburg 36, Germany

    M. Dietrich

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© 2011 Springer Verlag

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Vöhringer, HF., Arasteh, K., Hornscheidt, M., L’age, M. (2011). Pharmakologie von Pentamidin. In: Dietrich, M. (eds) Die Pneumocystis carinii Pneumonie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74771-7_8

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  • DOI: https://doi.org/10.1007/978-3-642-74771-7_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51177-9

  • Online ISBN: 978-3-642-74771-7

  • eBook Packages: Springer Book Archive

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