Bestimmung der Knochendichte mittels Doppelphotonenabsorptionsmessung (DPA) bei Patienten mit Asthma bronchiale unter Kortikoiddauertherapie

  • K. Dohm
  • J. Semler
Conference paper

Summary

Bone mineral content was measured by dual photon-absorption densitometry (DPA) in 66 patients of either sex (aged 13–58 years) with bronchial asthma being on long-term steroid treatment for at least two years. The results of DPA were correlated with the evaluation of questionnaire covering the main demographic data. Out of all patients 33.3% displayed a diminished bone mass in L2-L3 (female 40.5%; male 20.8%). Excluding female patients in the post-menopause, only 22.7% of the remaining female patients showed a loss in bone density. Since only a minority of patients with chronic asthma being on long-term corticoid treatment develop signs of osteoporosis, the risk patients being prone to a corticoid related bone tissue loss have to be detected. DPA appears to be a very sensitive method for routine screening of asthmatics on corticoids.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Adinoff AD, Hollister JR (1983) Steroid induced fractures and bone loss in patients with asthma. N Engl J Med 309:265–268PubMedCrossRefGoogle Scholar
  2. 2.
    Heuck F (1967) Radiologische Aspekte der Osteoporose. Dtsch Med Wochenschr 92:2272–2277PubMedCrossRefGoogle Scholar
  3. 3.
    Kapp S (1986) Messung des KMG mit der Zweistrahl-Photonenabsorptionsmethode zur Quantifizierung der Osteoporose. ÄRP 11:585–594Google Scholar
  4. 4.
    Katz RD (1985) Recent advances in the early diagnosis of osteoporosis. A review. MMJ 34:889–895Google Scholar
  5. 5.
    Kessler D, Meister W (1985) Untersuchungen zur Osteoporose bei Kortikoidtherapie von Patienten mit chron. obstruktiven Atemwegserkrankungen. Z Erkrank Atm-Org 165:248–254Google Scholar
  6. 6.
    Krokowski E (1968) Die röntgenologische Substanzanalyse des Knochens. Prinzip u. praktische Durchführung. Fortschr Röntgenstr 108:394–400CrossRefGoogle Scholar
  7. 7.
    Krokowski E (1972) Kortikoid-Osteoporose. Medizinische Klinik 36:1149–1157Google Scholar
  8. 8.
    Mueller MN (1976) Effects of corticosteroids on bone mineral in rheumatic arthritis and asthma. AJR 126:1300Google Scholar
  9. 9.
    Ringe JD, Wanner HW (1986) Früherkennung der Osteoporose. Dtsch med Wschr 111:954–958PubMedCrossRefGoogle Scholar
  10. 10.
    Seidin DW, Esser PD, Alderson PO (1988) Comparison of bone density measurements from different skeletal sites. J Nucl Med 29:168–173Google Scholar
  11. 11.
    Ziegler R (1988) Klinik der Glucocorticoidinduzierten Osteoporose. IV. Arbeitstagung der Sektion Calciumregulierende Hormone und Knochenstoffwechsel der deutschen Gesellschaft für Endokrinologie, HamburgGoogle Scholar

Copyright information

© Springer-Verlag · Heidelberg 1989

Authors and Affiliations

  • K. Dohm
    • 1
  • J. Semler
    • 1
  1. 1.I. Medizinische AbteilungUniversitätsklinikum Rudolf Virchow, Standort WeddingBerlin 65Germany

Personalised recommendations