Kalzium- und Phosphatsupplementierung bei Frühgeborenen unter 1500g Geburtsgewicht zur Prävention der Osteopenie

  • J. Kreuder
  • A. Otten
  • H. L. Reiter
  • G. Maasberg
Conference paper


Osteopenia occurs frequently in very low birthweight infants due to calcium and phosphate deficiency. The possibility of prevention was studied in thirty preterm infants with birth-weight under 1.500 gm. Calcium intake varied from 2.5 vs. 3.75 vs. 5 mmol/kg/day, phosphate was offered in a dose of 2.5 mmol/kg/day. 40% of infants with low calcium dose showed an activity of serum alkaline phosphatase greater than 700 IU/l which is defined as a reliable marker for osteopenia. High calcium doses resulted in an increased risk for hypercalcuria (40%) (p < 0.05). Half of infants with hypercalcuria developed typical signs of nephrocalcinosis on ultrasound examination. Medium intake of calcium reduced the incidence of osteopenia at a low risk of nephrocalcinosis. We conclude, that a calcium intake of 3.75 mmol/kg/day in combination with phosphate 2.5 mmol/kg/day is sufficient for adequate bone mineralization. Calcium excretion in urine has to be observed for early diagnosis of nephrocalcinosis.


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Copyright information

© Springer-Verlag · Heidelberg 1989

Authors and Affiliations

  • J. Kreuder
    • 1
  • A. Otten
    • 1
  • H. L. Reiter
    • 1
  • G. Maasberg
    • 1
  1. 1.Zentrum für KinderheilkundeKlinikum der Justus-Liebig-UniversitätGießenGermany

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