Die nichtkollagenen ossären Strukturproteine in der Differentialdiagnose des Osteosarkoms

Summary

In a comparative immunohistochemical study, polyclonal antibodies directed against non-collagenous osseous structure proteins were employed in osteosarcomas, fibrosarcomas, chondrosarcomas, liposarcomas, and malignant fibrous histiocytomas. Osteonectin, osteocalcin and the bone sialoproteins I and II showed marked positive immunoreactions in all osteosarcomas at different levels of differentiation. In fibrosarcomas as well as in chondrosarcomas a slight immunoreaction was found, where as it was negative in all other soft tissue tumors. Thus, due to their high bone specifity, the demonstration of non-collagenous osseous structure proteins is of high value in the differential diagnostic differentiation from other non-osteoblastic malignant bone tumors, most of all in cases where osteoid could not be demonstrated in the small bioptic specimens.