Osteopenie bei Ratten mit arzneimittelbedingter Mucopolysaccharidose

  • A. Peters
Conference paper

Summary

Tilorone, a drug with immunostimulatory activities, interferes with the lysosomal degradation of sulfated glycosaminoglycans (sGAG) in rats and causes osteopenia reminiscent of that occuring in patients with inherited mucopolysaccharidosis (MPS). While osteopenia in such patients is thought to result from impaired enchondral ossification, in rats it appears to be due to accelerated resorption of the primary spongiosa.

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Literatur

  1. 1.
    Aarskog D, Aksnes L, Lehmann V (1980) Low 1,25-dihydroxyvitamin D in heparin-induced osteopenia. Lancet 2:650PubMedCrossRefGoogle Scholar
  2. 2.
    Anderson CE, Crane JT, Harper HA, Hunter TW (1962) Morquio’s disease and dysplasia epiphysalis multiplex. J Bone Joint Surg 44A:295–306Google Scholar
  3. 3.
    Dawson IMP (1954) The histology and histochemistry of gargoylism. J Path Bact 67:587–604PubMedCrossRefGoogle Scholar
  4. 4.
    Gupta DK, Gieselmann V, Hasilik A, v Figura K (1984) Tilorone acts as a lysosomotropic agent in fibroblasts. Hoppe-Seyler’s Z Physiol Chem 365: 859–866PubMedCrossRefGoogle Scholar
  5. 5.
    Lüllmann-Rauch R (1983) Tilorone-induced lysosomal storage mimicking the features of mucopolysaccharidosis and lipidosis in rat liver. Virchows Arch (Cell Pathol) 44:355–368CrossRefGoogle Scholar
  6. 6.
    Lüllmann-Rauch R, Michel G, Peters A (1988) Mucopolysaccharidosis-like cellular alterations in chondrocytes of rats treated with tilorone. Exp Molec Pathol 49:279–289CrossRefGoogle Scholar
  7. 7.
    Prokopek M (1989) Drug-induced mucopolysaccharidosis in rats. Naunyn-Schmiedeberg’s Arch Pharmacol 339:R8Google Scholar
  8. 8.
    Schenk EA, Haggerty J (1964) Morquio’s disease: A radiologic and morphologic study. Pediatrics 34:839–850PubMedGoogle Scholar
  9. 9.
    Spranger JW, Langer LE, Wiedemann H-R (1974) Bone dysplasias. In: An atlas of constitutional disorders of skeletal development. Gustav Fischer Verlag, Stuttgart, 143–183Google Scholar

Copyright information

© Springer-Verlag · Heidelberg 1989

Authors and Affiliations

  • A. Peters
    • 1
  1. 1.Anatomisches InstitutUniversität KielKielGermany

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