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Radioruthenium-Labeled Compounds for Diagnostic Tumor Imaging

  • Conference paper
Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy

Part of the book series: Progress in Clinical Biochemistry and Medicine ((PCBM,volume 10))

Abstract

Among the various radionuclides of ruthenium, 97Ru and 103Ru have proven to be quite attractive for in vitro and in vivo research investigations. Ruthenium-97, in particular, has excellent nuclear decay characteristics (t1/2 69.6 h; deday mode by electron capture; 216 keV gamma, 86%; no betas) and thus is a promising radionuclide for diagnostic imaging applications. Compared to other commonly used intermediate half-life nuclides (e.g., 67Ga, 111In), 97Ru provides marked improvement in image quality and imparts significantly less radiation dose to the patient. No-carrier-added 97Ru is routinely prepared at the Brookhaven Linac Isotope Producer (BLIP) from proton spallation of high-purity rhodium, using the 103Rh (p, 2p5n) 97Ru reaction. Ruthenium-103 (available commercially as a fission product), although not particularly appropriate for imaging, has nonetheless proven useful for chemical, in vitro, and preclinical studies.

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Authors and Affiliations

  1. Medical Department Brookhaven National Laboratory, Upton, NY, 11973, USA

    Suresh C. Srivastava & Leonard F. Mausner

  2. Department of Chemistry, Boston College, Chestnut Hill, MA, 02167, USA

    Michael J. Clarke

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  1. Suresh C. Srivastava
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  2. Leonard F. Mausner
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  3. Michael J. Clarke
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Editors and Affiliations

  1. Département de Chimie Biologique, Faculté de Médecine de Bicêtre, Université de Paris Sud, Hôpital de Bicêtre, F-94270, Bicêtre, France

    Etienne Baulieu

  2. Department of Pathology, School of Medicine, University of North Carolina, Chapel Hill, NC, 27514, USA

    Donald T. Forman

  3. Karolinska Institutet Institutionen för Medicinsk Kemi, Box 60400, S-104 01, Stockholm, Sweden

    Magnus Ingelman-Sundberg

  4. Institut für Biochemie, Universität Köln, An der Bottmühle 2, D-5000, Köln, Germany

    Lothar Jaenicke

  5. Sunnybrook Medical Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, Ontario, Canada

    John A. Kellen

  6. Department of Biochemistry Faculty of Medicine, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan

    Yoshitaka Nagai

  7. Immunochemistry Research, Evanston Hospital, Northwestern University, 2650 Ridge Avenue, 60201, Evanston, IL, USA

    Georg F. Springer

  8. Klinikum der Johann Wolfgang Goethe-Universität, Gustav-Embden-Zentrum, Theodor Stern Kai 7, D-6000, Frankfurt a. M. 70, Germany

    Lothar Träger

  9. Zentralinstitut für Herz- und Kreislauf-Forschung, Akademie der Wissenschaften der DDR, Lindenberger Weg 70, DDR-1115, Berlin-Buch, Germany

    Liane Will-Shahab

  10. Hormone Receptor Laboratory, James Graham Brown Cancer Center, University of Louisville, 40292, Louisville, KY, USA

    James L. Wittliff

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Srivastava, S.C., Mausner, L.F., Clarke, M.J. (1989). Radioruthenium-Labeled Compounds for Diagnostic Tumor Imaging. In: Baulieu, E., et al. Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy. Progress in Clinical Biochemistry and Medicine, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74760-1_6

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