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New Ruthenium Complexes for the Treatment of Cancer

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Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy

Part of the book series: Progress in Clinical Biochemistry and Medicine ((PCBM,volume 10))

Abstract

The aim of developing new tumor-inhibiting ruthenium complexes, in particular compounds which act against tumors that have been chemoresistant up to now, has led us to the synthesis of different classes of ruthenium complexes. These were selected for further evaluation on the basis of increase in survival time in the P388 tumor model and water-solubility. The water-soluble ruthenium complexes coordinated with heterocycle ligands intrans-position, HB(RuB2Cl4), and the corresponding pentachloro derivatives, (HB)2(RuBCl5), were identified as being the most active ones. Their chemical properties were investigated by means of x-ray analyses, Mössbauer spectra, NMR spectra, and other methods. Their galenic formulation was relatively easy to establish owing to their solubility in water or in physiological saline. Stability of the complexes turned out to be sufficient for infusion therapy. Antitumor activity of such compounds was confirmed not only in the P388 tumor model but also in the Walker 256 carcinosarcoma, the Stockholm Ascitic tumor, the subcutaneously growing B 16 melanoma, the intramusculary growing sarcoma 180 and the AMMN-induced colorectal tumors of the rat.

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Author information

Authors and Affiliations

  1. Anorganisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 270, 6900, Heidelberg, Germany

    B. K. Keppler, M. Henn, U. M. Juhl & R. Niebl

  2. Institut für Toxikologie und Chemotherapie am Deutschen Krebsforschungszentrum, Im Neuenheimer Feld 280, 6900, Heidelberg, Germany

    M. R. Berger

  3. Physik-Department E15, Technische Universität München, 8046, Garching, Germany

    F. E. Wagner

Authors
  1. B. K. Keppler
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  2. M. Henn
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  3. U. M. Juhl
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  4. M. R. Berger
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  5. R. Niebl
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  6. F. E. Wagner
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Editor information

Editors and Affiliations

  1. Département de Chimie Biologique, Faculté de Médecine de Bicêtre, Université de Paris Sud, Hôpital de Bicêtre, F-94270, Bicêtre, France

    Etienne Baulieu

  2. Department of Pathology, School of Medicine, University of North Carolina, Chapel Hill, NC, 27514, USA

    Donald T. Forman

  3. Karolinska Institutet Institutionen för Medicinsk Kemi, Box 60400, S-104 01, Stockholm, Sweden

    Magnus Ingelman-Sundberg

  4. Institut für Biochemie, Universität Köln, An der Bottmühle 2, D-5000, Köln, Germany

    Lothar Jaenicke

  5. Sunnybrook Medical Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, Ontario, Canada

    John A. Kellen

  6. Department of Biochemistry Faculty of Medicine, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan

    Yoshitaka Nagai

  7. Immunochemistry Research, Evanston Hospital, Northwestern University, 2650 Ridge Avenue, 60201, Evanston, IL, USA

    Georg F. Springer

  8. Klinikum der Johann Wolfgang Goethe-Universität, Gustav-Embden-Zentrum, Theodor Stern Kai 7, D-6000, Frankfurt a. M. 70, Germany

    Lothar Träger

  9. Zentralinstitut für Herz- und Kreislauf-Forschung, Akademie der Wissenschaften der DDR, Lindenberger Weg 70, DDR-1115, Berlin-Buch, Germany

    Liane Will-Shahab

  10. Hormone Receptor Laboratory, James Graham Brown Cancer Center, University of Louisville, 40292, Louisville, KY, USA

    James L. Wittliff

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© 1989 Springer-Verlag Berlin Heidelberg

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Keppler, B.K., Henn, M., Juhl, U.M., Berger, M.R., Niebl, R., Wagner, F.E. (1989). New Ruthenium Complexes for the Treatment of Cancer. In: Baulieu, E., et al. Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy. Progress in Clinical Biochemistry and Medicine, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74760-1_3

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  • DOI: https://doi.org/10.1007/978-3-642-74760-1_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74762-5

  • Online ISBN: 978-3-642-74760-1

  • eBook Packages: Springer Book Archive

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