Abstract
One night Milan unexpectedly called at our flat in central Prague in an elated mood and asked for a cup of strong, black coffee. However, before coffee was prepared, he dozed off on the sofa. After a while, we opted to make him comfortable with a pillow and blanket and went to bed. In the middle of the night we were woken by the weight of Milan’s body diagonally across us on the bed. Milan, while asleep, resisted all our efforts to move him into a parallel position in the middle of the bed. Defeated, we retreated next door and went to sleep on the floor. In the morning, amazed by the situation, Milan disappeared and soon returned with an enormous bouquet of flowers for my wife Lida.
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References
Bloom BR, Mehra V (1984) Immunological unresponsiveness in leprosy. Immunol Rev 80: 5
Bothamley GH, Udani PM, Rudd R, Festenstein F, Ivanyi J (1988) Antibody levels in smear positive and smear negative thoracic tuberculosis of adults and children. Eur J Clin Microbiol Inf 7:639
Bothamley GH, Beck J, Schreuder G, D’Amaro J, de Vries RRP, Kardjito T, Ivanyi J (1989) HLA-DR2 and DQwl association with tuberculosis and antibody levels to the 38kDa antigen. J Inf Dis 159: 549–555
Cox JH, Ivanyi J (1988) The role of host factors for the chemotherapy of BCG infection in inbred strains of mice. Acta Pathol Microbiol Immunol Scand 96: 927
Cox JH, Ivanyi J, Young DB, Lamb JR, Syred AD, Francis M (1989) Orientation of epitopes influences the immunogenicity of synthetic peptide dimers. Eur J Immunol (in press)
Hart P D’arcy, Rees RJW (1950) Enhancing effect of cortisone on tuberculosis in the mouse. Lancet 2:391
Ivanyi J (1986) Pathogenic and protective interactions in mycobacterial infections. Clin Immunol Allergy 60: 127–157
Ivanyi J, Bothamley GH, Jackett PS (1988 a) Immunodiagnostic assays for tuberculosis and leprosy. Br Med Bull 44: 635–649
Ivanyi J, Sharp K, Jackett P, Bothamley G (1988 b) Immunological study of the defined constituents of mycobacteria. Springer Semin Immunopathol 10: 279
Jackett P, Bothamley G, Batra HV, Mistry A, Young DB, Ivanyi J (1988) Epitope and whole antigen molecule specificities in the serology of tuberculosis. J Clin Microbiol 26: 2313
Kaufmann SHE (1988) CD8+ T lymphocytes in intracellular microbial infections. Immunol Today 9: 168–174
Lamb JR, Ivanyi J, Rees ADM, Rothbard JB, Howland K, Young RA, Young DB (1987) Mapping of T cell epitopes using recombinant antigens and synthetic peptides. EMBO J 6: 1245
Lovik M, Closs O (1982) Repeated delayed-type hypersensitivity reactions against Mycobacterium lepraemurium antigens at the infection site do not affect bacillary multiplication in C3H mice. Infect Immun 36: 768
Mendez-Samperio P, Lamb J, Bothamley G, Stanley P, Ellis C, Ivanyi J (1989) Molecular study of the T cell repertoire in family contacts and patients with leprosy. J Immunol (In press)
Modlin RL, Rea TH (1988) Immunopathology of leprosy granulomas. Springer Semin Immunopathol 10: 359
Moreno C, Angela M, Lamb J (1988) The inhibitory effects of mycobacterial lipoarabinomannan and polysaccharides upon polyclonal and monoclonal human T cell proliferation. Clin Exp Immunol 74: 206
Mustafa AS, Kvalheim G, Degré M, Godai T (1986) Mycobacterium bovis BCG-induced human T cell clones from BCG-vaccinated healthy subjects: antigen specificity and lymphokine production. Infect Immun 53: 491
Nogueira N, Kaplan G, Levy E et al. (1983) Defective gamma interferon production in leprosy: reversal with antigen and IL-2. J Exp Med 158: 2165–2170
Prasad HK, Mishra RS, Nath I (1987) Phenolic glycolipid-I of Mycobacterium leprae induces general suppression of in vitro concanavalin a responses unrelated to leprosy type. J Exp Med 165: 239
Rook GAW, Carswell JW, Stanford JL (1976) Preliminary evidence for the trapping of antigen-specific lymphocytes in the lymphoid tissu of “anergic” tuberculosis patients. Clin Exp Immunol 16:129–132
Sengupta U, Sinha S, Ramu G, Lamb J, Ivanyi J (1987) Suppression of delayed hypersensitivity skin reactions to tuberculin by M. lepare antigens in patients with lepromatous and tuberculoid leprosy. Clin Exp Immunol 68: 58
Young DB, Lathigra R, Hendrix R, Sweetser D, Young RA (1988) Stress proteins are immune targets in leprosy and tuberculosis. Proc Natl Acad Sci USA 85: 4267–4270
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Ivanyi, J. (1989). Immunological Analysis of Mycobacterial Disease. In: Ivanyi, P. (eds) Realm of Tolerance. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74712-0_16
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DOI: https://doi.org/10.1007/978-3-642-74712-0_16
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