Abstract
My career during the last 20 years can be likened to the zooming motion of a photographic lens, starting from a large field, taking in progressively smaller sections, and finally focusing on a single detail — zeroing in on the H-2 complex. It was not an uninterrupted motion, for during those 20 years I have also been busy raising three children, two dogs, and one husband — in that order of difficulty. Here, instead of reviewing the entire field encompassed by my studies, I will present five stops of the zoom lens: five snapshots representing — not necessarily in chronological order — five stages in my career. They brought me exponentially ever closer to the H-2 complex, until they landed me in the complex itself.
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References
Bach FH, Widmer MB, Segali M, Bach ML, Klein J (1972) Genetic and immunological complexity of major histocompatibility regions. Science 176: 1024–1037
Carter TC, Lyon MF, Phillips RJS (1955) Gene-tagged chromosome translocations in eleven stocks of mice. J Genetics 53: 154–166
David CS, Shreffler DC, Frelinger JA (1973) New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex. Proc Natl Acad Sci USA 70: 2509–2514
Figueroa F, Davis WC, Klein J (1981) Ten monoclonal antibodies detecting antigenic determinants on class I H-2 molecules. Immunogenetics 14: 177–180
Figueroa F, Klein D, Tewarson S, Klein J (1982) Evidence for placing the Neu-1 locus within the mouse H-2 complex. J Immunol 129: 2089–2093
Hauptfeld V, Klein D, Klein J (1973) Serological identification of an Ir-region product. Science 181:167–169
Klein D, Klein J (1982) Polymorphism of the Apl(Neu-l) locus in the mouse. Immunogenetics 16: 181–184
Klein D, Merchant DJ, Klein J, Shreffler DC (1970) Resistance of H-2 and some non-H-2 antigens on long-term cultured mouse cell lines. INCI 44: 1149–1160
Klein D, Tewarson S, Figueroa F, Klein J (1982) The minimal length of the differential segment in H-2 congenie lines. Immunogenetics 16: 319–328
Klein D, Zaleska-Rutczynska Z, Davies WC, Figueroa F, Klein J (1987) Monoclonal antibodies specific for mouse class I and class II Mhc determinants. Immunogenetics 25: 351–355
Klein J (1975) Biology of the mouse histocompatibility-2 complex. Springer, Berlin Heidelberg New York
Klein J (1986) Natural history of the major histocompatibility complex. Wiley, New York
Klein J, Klein D (1972) Position of the translocation break T(2;9)138Ca in linkage group IX of the mouse. Genet Res Camb 19: 177–179
Klein J, Klein D (1987) Mouse inbred and congenic strains. Methods Enzymol 150K: 163–196
Klein J, Nagy ZA (1982) Mhc restriction and Ir genes. Adv Cancer Res 37: 233–317
Klein J, Klein D, Shreffler DC (1970) H-2 types of translocation stocks T(2;9)138Ca, T(9;13)190Ca and an H-2 recombinant. Transplantation 10: 309–320
Klein J, Klein D, Figueroa F (1986) Should the neuraminidase-1 locus be considered as part of the major histocompatibility complex? Hum Immunol 15: 396–403
Köhler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495–497
Landais D, Beck BN, Buerstedde JM, Degraw S, Klein D, Koch N, Murphy D, Pierres M, Tada T, Yamamoto K, Benoist Ch, Mathis D (1986) The assignment of chain specificities for anti-la monoclonal antibodies using L cell transfectants. J Immunol 137: 3002–3005
McDevitt HO, Deak BD, Shreffler DC, Klein J, Stimpfling JH, Snell GD (1972) Genetic control of the immune response. Mapping of the Ir-1 locus. J Exp Med 135: 1259–1278
Nizetić D, Figueroa F, Klein J (1984) Evolutionary relationships between the t and H-2 haplotypes in the house mouse. Immunogenetics 19: 311–320
Stimpfling, JH, Reichert AE (1970) Strain C57BL/10ScSn and its congenie resistant sublines. Transplant Proc 2: 39–47
Womack JE, Yan DLS, Portier M (1981) Gene for neuraminidase activity on chromosome 17 near H-2: pleiotropic effects on multiple hydrolases. Science 212: 6–65
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© 1989 Springer-Verlag Berlin Heidelberg
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Klein, D. (1989). Zeroing in on the H-2 Complex. In: Ivanyi, P. (eds) Realm of Tolerance. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74712-0_13
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DOI: https://doi.org/10.1007/978-3-642-74712-0_13
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