Advertisement

HLA Subtypes

  • H. Mervart
Conference paper

Abstract

The major histocompativility complex (MHC) in man is known as the HLA system and has been localized to a small segment of chromosome 6. The HLA complex is the most polymorphic genetic system found in humans. It is composed of a series of at least 11 closely linked genes. Based on the most recent nomenclature report (Bodmer et al. 1988) the World Health Organization (WHO) recognizes the expressed products of seven multiallelic loci (HLA-A, -B, -C, -D, -DR, -DP, and -DQ) along with the existence of three other genes (HLA-E, -DN, and -DO).

Keywords

Panel Member Panel Cell Schematic Repre Bw58 Cell International Histocompatibility Workshop 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Biddison WE, Kostyu DD, Strominger JL, Krangel MS (1982) Delineation of immunologically and biochemically distinct HLA-A2 antigens. J Immunol 129: 730–734PubMedGoogle Scholar
  2. Bodmer WF, Albert E, Bodmer JG, Dupont B, Mach B, Mayr W, Sasazuki T, Schreuder GMT, Svejgaard A, Terasaki PI (for the WHO Nomenclature Committee) (1988) Nomenclature for factors of the HLA system, 1987. Vox Sang 55: 119–126CrossRefGoogle Scholar
  3. Dupont B (ed) (1988) Tenth International Histocompatibility Workshop Newsletter, vol 2, no 1Google Scholar
  4. Dupont B (ed) (1989) Immunobiology of HLA, vols 1, 2. Springer, Berlin Heidelberg New York (in press)Google Scholar
  5. Duquesnoy R, Trucco M (1988) Genetic basis of cell surface polymorphisms encoded by the major histocompatibility complex in humans. CRC Crit Rev Immunol: 103-145Google Scholar
  6. Ezquerra A, Domenach N, van der Poel J, Strominger JL, Vega MA, Lopez de Castro JA (1986) Molecular analysis of an HLA-A2 functional variant CLA defined by cytolytic T lymphocytes. J Immunol 137: 1642–1649PubMedGoogle Scholar
  7. Hogan KT, Clayberger C, Bernhard EJ, Walk SF, Ridge JP, Parham P, Krensky AM, Engelhard VH (1988 a) Identification by site-directed mutagenesis of amino acid residues contributing to serologic and CTL-defined epitope differences between HLA-A2.1 and HLA-2.3. J Immunol 141: 2519–2525PubMedGoogle Scholar
  8. Hogan KT, Clayberger C, Le A-X, Walk SF, Ridge JP, Parham P, Krensky AM, Engelhard VH (1988b) Cytotoxic T-lymphocyte defined epitope differences between HLA-A2.1 and HLA-2.2 map to two distinct regions of the molecule. J Immunol 141: 4005–4011PubMedGoogle Scholar
  9. Kennedy LJ, Wallace LE, Madrigal JA, Rickinson AB, Bodmer JG (1987) New HLA-A2 variants defined by monoclonal antibodies and cytotoxic T lymphocytes. Immunogenetics 26:115–160CrossRefGoogle Scholar
  10. Klein J (1986) Natural history of the major histocompatibility complex. Wiley, New YorkGoogle Scholar
  11. Neefjes JJ, Breur-Vriesendorp S, van Seventer GA, Ivanyi P, Ploegh HL (1986) An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes. Hum Immunol 16: 169–181PubMedCrossRefGoogle Scholar
  12. Parham P (1988) Function and polymorphism of human leukocyte antigen-A, B, C molecules. Am J Med 85[Suppl6A]:2–5PubMedCrossRefGoogle Scholar
  13. Russo C, Ng A-K, Pellegrino MA, Ferrone S (1983) The monoclonal antibody CR11-351 discriminates HLA-A2 variants identified by T cells. Immunogenetics 18: 23–35PubMedCrossRefGoogle Scholar
  14. Tiwari JL, Terasaki PI (1985) HLA and disease associations. Springer, Berlin Heidelberg New YorkCrossRefGoogle Scholar
  15. Yang SY, Chang A, Olivero R, Relias V, Yunis EY (1985) IEF patterns of HLA-B13 antigens from Orientals and Caucasians. Immunogenetics 21: 125–134PubMedCrossRefGoogle Scholar
  16. Yang E, Wong KH, Ferrone S, Mervart H (1986) Recognition of a variant of HLA-A2 with a human monospecific alloantiserum. Hum Immunol 17: 145–146 (abstr)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. Mervart

There are no affiliations available

Personalised recommendations